4-Hydroxybenzophenone

Product Name: 4-Hydroxybenzophenone
CAS No.: 1137-42-4
Chemical Name: 4-Hydroxybenzophenone
Synonyms: POB;P-HYDROXYBENZOPHENONE;4-Hydroxydiphenylketone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;4-BENZOYLPHENOL;P-BENZOYLPHENOL;PARA-BENZOYLPHENOL
CBNumber: CB9237221
Molecular Formula: C13H10O2
Formula Weight: 198.22
MOL File: 1137-42-4.mol

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4-Hydroxybenzophenone Property

Melting point:: 132-135 °C(lit.)
Boiling point:: 260-262°C 42mm
Density: 1.1184 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.5954 (estimate)
Flash point:: 260-262°C/24mm
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 8.14±0.13(Predicted)
color: White to beige to brown
Water Solubility: Insoluble in water.
BRN: 777776
LogP: 1.6 at 35℃
CAS DataBase Reference: 1137-42-4(CAS DataBase Reference)
NIST Chemistry Reference: Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)
EPA Substance Registry System: Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37-24/25-36
WGK Germany: 2
RTECS: PC4959775
Hazard Note: Irritant
TSCA: Yes
HS Code: 29145000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H20202
Product name: 4-Hydroxybenzophenone
Purity: 98%
Packaging: 25g
Price: $67.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: H20202
Product name: 4-Hydroxybenzophenone
Purity: 98%
Packaging: 100g
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20661
Product name: 4-Hydroxybenzophenone
Purity: for synthesis
Packaging: 25g
Price: $50.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20661
Product name: 4-Hydroxybenzophenone
Purity: for synthesis
Packaging: 100g
Price: $169
Updated: 2024/03/01

TCI Chemical

Product number: H0222
Product name: 4-Hydroxybenzophenone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $45
Updated: 2024/03/01

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4-Hydroxybenzophenone Chemical Properties,Usage,Production

Chemical Properties

white to beige fine crystalline powder

Uses

4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.

Uses

Metabolite of benzophenone.

Definition

ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.

Preparation

Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0

Flammability and Explosibility

Not classified

Purification Methods

Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]

4-Hydroxybenzophenone Preparation Products And Raw materials

Raw materials

Aluminum chloride Phenyl benzoate

Preparation Products

Clomiphene Citrate 4-[2-(diethylamino)ethoxy]benzophenone alpha-[4-[2-(diethylamino)ethoxy]phenyl]-alpha-phenylphenethyl alcohol

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4-Hydroxybenzophenone Suppliers

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View Lastest Price from 4-Hydroxybenzophenone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 4-Hydroxybenzophenone 1137-42-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-04-24

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 4-Hydroxybenzophenone 1137-42-4
Price: US $99.00-66.00/kg
Min. Order: 0.0010000000474974513kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Hydroxybenzophenone 1137-42-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

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1137-42-4