1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- Product Name
- 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 35120-18-4
- Chemical Name
- 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 1-bromocyclobutane-1-carboxylate;ETHYL 1-BROMOCYCLOBUTANECARBOXYLATE;NSC 135010;1-Bromo-1-carbethoxycyclobutane;1-Ethoxycarbonyl-1-bromocyclobutane;Ethyl1-bromocyclobutanecarboxylate,95%;Ethyl 1-broMocyclobutanecarboxylate 96%;Ethyl 1-bromocyclobutanecarboxylate,96%;1-Bromocyclobutanecarboxylic acid ethyl;ethyl alpha-bromocyclobutanecarboxylate
- CBNumber
- CB0288831
- Molecular Formula
- C7H11BrO2
- Formula Weight
- 207.07
- MOL File
- 35120-18-4.mol
1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Property
- Boiling point:
- 85-88 °C12 mm Hg(lit.)
- Density
- 1.279 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.471(lit.)
- Flash point:
- 175 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- color
- Clear colorless
- Stability:
- Light Sensitive
- InChIKey
- UTVNSHXHFRIXMM-UHFFFAOYSA-N
- CAS DataBase Reference
- 35120-18-4
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29162000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 197297
- Product name
- Ethyl 1-bromocyclobutanecarboxylate
- Purity
- 96%
- Packaging
- 5g
- Price
- $111
- Updated
- 2023/01/07
- Product number
- E1245
- Product name
- Ethyl 1-Bromocyclobutanecarboxylate
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- E1245
- Product name
- Ethyl 1-Bromocyclobutanecarboxylate
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- E900295
- Product name
- Ethyl 1-bromocyclobutanecarboxylate
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 059021
- Product name
- Ethyl alpha-bromocyclobutanecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Uses
Ethyl 1-bromocyclobutanecarboxylate was used in the synthesis of 1?aminocyclobutane carboxylic acid.
Synthesis
14924-53-9
35120-18-4
To a solution of ethyl cyclobutanecarboxylate (10 g) in carbon tetrachloride (100 mL) was sequentially added N-bromosuccinimide (NBS, 20.83 g) and azobisisobutyronitrile (AIBN, 1.281 g). The reaction mixture was stirred at 80 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) and the mixture was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution (50 mL), water (50 mL) and saturated saline (50 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:1) to afford the target product ethyl 1-bromocyclobutanecarboxylate (10 g) as a yellow oil.1H NMR (400MHz, CDCl3) δ: 4.26 (q, J=14.4,7.2Hz, 2H), 2.95-2.88 (m, 2H), 2.67- 2.59 (m, 2H), 2.26-2.21 (m, 1H), 1.91-1.86 (m, 1H), 1.32 (t, J=7.2Hz, 3H).
References
[1] Journal of Organic Chemistry, 2012, vol. 77, # 23, p. 11002 - 11005
[2] Chemical Communications, 2015, vol. 51, # 42, p. 8773 - 8776
[3] Organic Letters, 2016, vol. 18, # 9, p. 2040 - 2043
[4] Patent: WO2018/15411, 2018, A1. Location in patent: Paragraph 0165; 0166; 0167; 0168; 0169; 0170
[5] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 11, p. 988 - 993
1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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- Country
- Americas
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- 23653
- Advantage
- 75
View Lastest Price from 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- ethyl 1-bromocyclobutane-1-carboxylate 35120-18-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER 35120-18-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER 35120-18-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-09