ChemicalBook > CAS DataBase List > 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

Product Name: 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
CAS No.: 35120-18-4
Chemical Name: 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethyl 1-bromocyclobutane-1-carboxylate;ETHYL 1-BROMOCYCLOBUTANECARBOXYLATE;NSC 135010;1-Bromo-1-carbethoxycyclobutane;1-Ethoxycarbonyl-1-bromocyclobutane;Ethyl1-bromocyclobutanecarboxylate,95%;Ethyl 1-broMocyclobutanecarboxylate 96%;Ethyl 1-bromocyclobutanecarboxylate,96%;1-Bromocyclobutanecarboxylic acid ethyl;ethyl alpha-bromocyclobutanecarboxylate
CBNumber: CB0288831
Molecular Formula: C7H11BrO2
Formula Weight: 207.07
MOL File: 35120-18-4.mol

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1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Property

Boiling point:: 85-88 °C12 mm Hg(lit.)
Density: 1.279 g/mL at 25 °C(lit.)
refractive index: n20/D 1.471(lit.)
Flash point:: 175 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
color: Clear colorless
Stability:: Light Sensitive
InChIKey: UTVNSHXHFRIXMM-UHFFFAOYSA-N
CAS DataBase Reference: 35120-18-4

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29162000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 197297
Product name: Ethyl 1-bromocyclobutanecarboxylate
Purity: 96%
Packaging: 5g
Price: $111
Updated: 2023/01/07

TCI Chemical

Product number: E1245
Product name: Ethyl 1-Bromocyclobutanecarboxylate
Purity: >96.0%(GC)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: E1245
Product name: Ethyl 1-Bromocyclobutanecarboxylate
Purity: >96.0%(GC)
Packaging: 5g
Price: $167
Updated: 2025/07/31

TRC

Product number: E900295
Product name: Ethyl 1-bromocyclobutanecarboxylate
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 059021
Product name: Ethyl alpha-bromocyclobutanecarboxylate
Purity: 95+%
Packaging: 1g
Price: $114
Updated: 2021/12/16

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1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

Ethyl 1-bromocyclobutanecarboxylate was used in the synthesis of 1?aminocyclobutane carboxylic acid.

Synthesis

14924-53-9

35120-18-4

To a solution of ethyl cyclobutanecarboxylate (10 g) in carbon tetrachloride (100 mL) was sequentially added N-bromosuccinimide (NBS, 20.83 g) and azobisisobutyronitrile (AIBN, 1.281 g). The reaction mixture was stirred at 80 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) and the mixture was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution (50 mL), water (50 mL) and saturated saline (50 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:1) to afford the target product ethyl 1-bromocyclobutanecarboxylate (10 g) as a yellow oil.1H NMR (400MHz, CDCl3) δ: 4.26 (q, J=14.4,7.2Hz, 2H), 2.95-2.88 (m, 2H), 2.67- 2.59 (m, 2H), 2.26-2.21 (m, 1H), 1.91-1.86 (m, 1H), 1.32 (t, J=7.2Hz, 3H).

References

[1] Journal of Organic Chemistry, 2012, vol. 77, # 23, p. 11002 - 11005
[2] Chemical Communications, 2015, vol. 51, # 42, p. 8773 - 8776
[3] Organic Letters, 2016, vol. 18, # 9, p. 2040 - 2043
[4] Patent: WO2018/15411, 2018, A1. Location in patent: Paragraph 0165; 0166; 0167; 0168; 0169; 0170
[5] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 11, p. 988 - 993

1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: ethyl 1-bromocyclobutane-1-carboxylate 35120-18-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Henan Aochuang Chemical Co.,Ltd.

Product: 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER 35120-18-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu Medichem Co. Ltd

Product: 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER 35120-18-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-09

35120-18-4, 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTERRelated Search:

ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE Ethyl5-bromo-1,3,4-thiadiazole-2-carboxylate TRANS,TRANS-3,4,5-TRIFLUOROPHENYL 4''-ETHYLBICYCLOHEXYL-4-CARBOXYLATE 4-cyanophenyl 4-trans-(4-ethylcyclohexyl)benzoate ethyl 2-(2-aminopyrimidin-4-yl)acetate ETHYL 4-CHLOROBUTYRATE 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 4-ETHYLBENZOIC ACID-4'-CYANOPHENYL ESTER Ethyl 4-(benzyloxy)-3-oxobutanoate ETHYL 4-METHYLOCTANOATE ethyl 5-oxo-DL-prolinate ETHYL 4-METHYLBENZOYLFORMATE Ethyl 5-AMinoopyrazolo[1,5-a]pyridine-3-carboxylate ETHYL 4-(2-CHLOROACETAMIDO)BENZOATE ethyl 2‐(2‐chloropyriMidin‐5‐yl)acetate Ethyl4-Methyl-2-(thiophen-2-yl)thiazole-5-carboxylate ETHYL (2-METHOXYBENZOYL)ACETATE ethyl 3-hydroxycyclohexanecarboxylate

1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

Cyclobutanecarboxylic acid, 1-bromo-, ethyl ester

ethyl alpha-bromocyclobutanecarboxylate

1-Bromocyclobutane-1-carboxylic acid ethyl ester

1-Bromocyclobutanecarboxylic acid ethyl

Ethyl 1-bromocyclobutanecarboxylate,96%

Ethyl 1-bromocyclobutane-1-carboxylate

NSC 135010

1-Bromo-1-carbethoxycyclobutane

1-Ethoxycarbonyl-1-bromocyclobutane

Ethyl 1-broMocyclobutanecarboxylate 96%

ETHYL 1-BROMOCYCLOBUTANECARBOXYLATE

Ethyl1-bromocyclobutanecarboxylate,95%

Ethyl 1-<WBR>bromocyclobutanecarboxylate

ethyl 1-bromocyclobutane-1-carboxylate - [E23222]

35120-18-4

38120-15-4

BrC4H6CO2C2H5

Building Blocks

C6 to C7

Organic Building Blocks

Esters

Carbonyl Compounds

C6 to C7

Carbonyl Compounds

Esters