ChemicalBook > CAS DataBase List > (1H-PYRAZOL-4-YL)METHANOL

(1H-PYRAZOL-4-YL)METHANOL

Product Name: (1H-PYRAZOL-4-YL)METHANOL
CAS No.: 25222-43-9
Chemical Name: (1H-PYRAZOL-4-YL)METHANOL
Synonyms: Pyrazole-4-methanol;1H-Pyrazole-4-Methanol;4-(HYDROXYMETHYL)PYRAZOLE;(1H-PYRAZOL-4-YL)METHANOL;4-HyroxyMethyl-1H-pyrazole;4-Hyroxymethyl-1H-pyrazol...;(1H-Pyrazol-4-Yl)Methanol(WX640336)
CBNumber: CB0301963
Molecular Formula: C4H6N2O
Formula Weight: 98.1
MOL File: 25222-43-9.mol

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(1H-PYRAZOL-4-YL)METHANOL Property

Boiling point:: 326.8±17.0 °C(Predicted)
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO
pka: 13.78±0.50(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C4H6N2O/c7-3-4-1-5-6-2-4/h1-2,7H,3H2,(H,5,6)
InChIKey: JRMKJOOJKCAEJK-UHFFFAOYSA-N
SMILES: N1C=C(CO)C=N1

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B529775
Product name: (1H-Pyrazol-4-yl)methanol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Ark Pharm

Product number: P000724503
Product name: (1H-Pyrazol-4-yl)methanol
Purity: 97%
Packaging: 100mg
Price: $12
Updated: 2021/12/16

Ark Pharm

Product number: P000724503
Product name: (1H-Pyrazol-4-yl)methanol
Purity: 97%
Packaging: 250mg
Price: $19
Updated: 2021/12/16

ApexBio Technology

Product number: C6614
Product name: 4-Hydroxymethylpyrazole
Packaging: 100mg
Price: $55
Updated: 2021/12/16

Ark Pharm

Product number: P000724503
Product name: (1H-Pyrazol-4-yl)methanol
Purity: 97%
Packaging: 1g
Price: $58
Updated: 2021/12/16

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(1H-PYRAZOL-4-YL)METHANOL Chemical Properties,Usage,Production

Uses

Callistephin (chloride) (Standard) is the analytical standard of Callistephin (chloride). This product is intended for research and analytical applications. Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin that can be found in strawberries and chokeberries.

Definition

ChEBI: 4-Hydroxymethylpyrazole is a member of pyrazoles.

Synthesis

37622-90-5

25222-43-9

In a flame-dried round-bottom flask (RBF), a suspension of lithium aluminum hydride (LAH, 45.2 mL, 45.2 mmol, 1 M in tetrahydrofuran (THF)) was cooled to 0°C. Subsequently, a solution of ethyl 1H-pyrazole-4-carboxylate (3.17 g, 22.6 mmol) dissolved in THF (20 mL) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and stirred overnight at room temperature. Upon completion of the reaction, the mixture was cooled in an ice bath and 1.36 mL of water and 10 mL of 1 M sodium hydroxide (NaOH) solution were added sequentially dropwise to carefully quench the reaction, followed by stirring for 20 min. Solid magnesium sulfate (MgSO4) was added to dry the reaction mixture, and stirring was continued at room temperature for 30 min after removal of the ice bath. The solids were removed by filtration through diatomaceous earth (CELITE) and the filter cake was washed with THF and methanol (MeOH), respectively. The filtrates were combined and evaporated to give the target product (1H-pyrazol-4-yl) methanol (1.75 g, 78.9% yield) as a white solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 500 MHz, DMSO-d6): δ 12.58 (broad single peak, 1H), 7.58 (single peak, 1H), 7.40 (single peak, 1H), 4.74 (triple peak, J = 5.5 Hz, 1H), 4.37 (double peak, J = 5.2 Hz, 2H).

References

[1] Patent: WO2017/40449, 2017, A1. Location in patent: Paragraph 00176
[2] Patent: WO2011/121555, 2011, A1. Location in patent: Page/Page column 206
[3] Patent: US2013/96119, 2013, A1. Location in patent: Paragraph 1626; 1627
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 4000
[5] Patent: WO2006/74925, 2006, A1. Location in patent: Page/Page column 48

(1H-PYRAZOL-4-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (1H-PYRAZOL-4-YL)METHANOL manufacturers

Career Henan Chemical Co

Product: (1H-PYRAZOL-4-YL)METHANOL 25222-43-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-11

25222-43-9, (1H-PYRAZOL-4-YL)METHANOLRelated Search:

ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 1-PHENYL-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 3-Aminopyrazole-4-carboxylic acid 4-Pyrazolecarboxylic acid ETHYL 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXYLATE 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-METHYL-5-NITRO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Ethyl pyrazole-4-carboxylate Dichlorosulfophenyl-3-methylpyrazolone (1,5-DIMETHYL-1H-PYRAZOL-3-YL)METHANOL (3,5-DIMETHYL-PYRAZOL-1-YL)-METHANOL,(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHANOL ETHYL 1-METHYL-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE METHYL 3-METHYL-5-(5-METHYLISOXAZOL-3-YL)-1H-PYRAZOLE-4-CARBOXYLATE

(1H-PYRAZOL-4-YL)METHANOL

4-(HYDROXYMETHYL)PYRAZOLE

Pyrazole-4-methanol

(1H-Pyrazol-4-Yl)Methanol(WX640336)

4-Hyroxymethyl-1H-pyrazol...

4-HyroxyMethyl-1H-pyrazole

1H-Pyrazole-4-Methanol

25222-43-9

Pyrrolidines ,Pyrroles