ChemicalBook > CAS DataBase List > LDN-212320

LDN-212320

Product Name
LDN-212320
CAS No.
894002-50-7
Chemical Name
LDN-212320
Synonyms
LDN-212320;OSU-0212320;LDN-0212320;LDN/OSU-0212320;LDN-0212320 Maleate;LDN 0212320 (LDN212320;LDN-212320, 10 mM in DMSO;LDN/OSU-0212320;LDN-0212320;OSU-0212320;3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine;(3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)
CBNumber
CB03034769
Molecular Formula
C17H15N3S
Formula Weight
293.39
MOL File
894002-50-7.mol
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LDN-212320 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (170.42 mM; Need ultrasonic)
form 
Powder
color 
White to gray
InChI
InChI=1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
InChIKey
DUUQLWDHNYFUPP-UHFFFAOYSA-N
SMILES
C1(SCC2=CC=CC=C2C)=NN=C(C2=NC=CC=C2)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21650
Product name
LDN-0212320
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
21650
Product name
LDN-0212320
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
21650
Product name
LDN-0212320
Packaging
25mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
21650
Product name
LDN-0212320
Packaging
50mg
Price
$419
Updated
2024/03/01
Tocris
Product number
5082
Product name
LDN212320
Purity
≥98%(HPLC)
Packaging
50
Price
$609
Updated
2021/12/16
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LDN-212320 Chemical Properties,Usage,Production

Uses

LDN 212320 is a small molecule activator of glutamate transporter EAAT2 translation, which provides neuroprotection and shows potential for the therapeutic treatment of neurodegenerative diseases.

in vivo

LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior[1].
LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC[1].
LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC[1].

Animal Model:Mice[1].
Dosage:10 or 20 mg/kg.
Administration:IP 24 h before the injection of formalin.
Result:Significantly attenuated licking and biting behavior during both phases 1 and 2 in a dose-dependent manner compared to formalin-injected mice.
Significantly (P < 0.01 or P < 0.001) reduced the licking and biting behavior.
Significantly increased preference for the displaced object (F3, 13 = 28.03, P < 0.01) compared to formalin-injected mice.
Significantly (P < 0.001) increased interaction time with the displaced object compared to formalin-injected mice.

IC 50

EAAT2

LDN-212320 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-212320 Suppliers

China 59 United Kingdom 2 United States 8 Global 69
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

894002-50-7, LDN-212320Related Search:

LDN-214117 LDN-193189 LDN212854 LDN-193189 HCl

  • LDN-212320
  • LDN-0212320
  • 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
  • (3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)
  • LDN/OSU-0212320
  • LDN/OSU-0212320;LDN-0212320;OSU-0212320
  • OSU-0212320
  • 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine
  • Pyridazine, 3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)-
  • LDN-0212320 Maleate
  • LDN0212320,LDN-212320,Glutamate transporter 1,OSU 0212320,inhibit,EAAT2,Inhibitor,OSU0212320,LDN212320,LDN 212320,GLT-1,LDN 0212320,Excitatory amino acid transporter 2
  • LDN-212320, 10 mM in DMSO
  • LDN 0212320 (LDN212320
  • 894002-50-7