Azido-PEG1-NHS ester
- Product Name
- Azido-PEG1-NHS ester
- CAS No.
- 1807530-06-8
- Chemical Name
- Azido-PEG1-NHS ester
- Synonyms
- AZIDO-PEG1-NHS;N3-PEG1-CH2CH2COONHS;Azido-PEG1-NHS ester;2,5-dioxopyrrolidin-1-yl 3-(2-azidoethoxy)propanoate;3-(2-Azidoethoxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB03062340
- Molecular Formula
- C9H12N4O5
- Formula Weight
- 256.22
- MOL File
- 1807530-06-8.mol
Azido-PEG1-NHS ester Property
- storage temp.
- -20°C, sealed storage, away from moisture and light
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- AS107909
- Product name
- N3-PEG1-CH2CH2COONHS
- Purity
- 97%
- Packaging
- 250mg
- Price
- $283
- Updated
- 2021/12/16
- Product number
- BP-21857
- Product name
- Azido-PEG1-NHSester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- B-1442
- Product name
- N3-PEG1-CH2CH2COONHS
- Purity
- 97%
- Packaging
- 1g
- Price
- $412.5
- Updated
- 2021/12/16
Azido-PEG1-NHS ester Chemical Properties,Usage,Production
Description
Azido-PEG1-NHS ester is a click chemistry PEG reagent with broad application. Azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Uses
Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG1-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG1-NHS ester manufacturers
- Product
- azido-PEG1-NHS ester 1807530-06-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >97.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23