ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

Product Name: ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
CAS No.: 4506-71-2
Chemical Name: ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
Synonyms: 105461;EOS-62180;NSC 99005;AKOS 92528;AKOS B000472;AKOS BBB/012;AKOS MSC-0429;ASISCHEM N39354;AKOS BBS-00004584;CBI-BB ZERO/004885
CBNumber: CB0312695
Molecular Formula: C11H15NO2S
Formula Weight: 225.31
MOL File: 4506-71-2.mol

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ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Property

Melting point:: 114-116 °C(lit.)
Boiling point:: 407.5±45.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 0.53±0.20(Predicted)
form: Fine Crystalline Powder
color: Yellow
InChI: InChI=1S/C11H15NO2S/c1-2-14-11(13)9-7-5-3-4-6-8(7)15-10(9)12/h2-6,12H2,1H3
InChIKey: CDYVTVLXEWMCHU-UHFFFAOYSA-N
SMILES: C12CCCCC=1C(C(OCC)=O)=C(N)S2
CAS DataBase Reference: 4506-71-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-22
Safety Statements: 36/37/39-26-22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P322Specific measures (see …on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 159182
Product name: Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $39.1
Updated: 2023/06/20

TCI Chemical

Product number: A1355
Product name: Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Purity: >98.0%(T)
Packaging: 10g
Price: $116
Updated: 2025/07/31

TRC

Product number: E899335
Product name: Ethyl2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: X0157
Product name: Ethyl2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
Packaging: 5g
Price: $26
Updated: 2021/12/16

AK Scientific

Product number: X0157
Product name: Ethyl2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
Packaging: 25g
Price: $66
Updated: 2021/12/16

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ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

yellow fine crystalline powder

Uses

Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate was used in the preparation of:

thienopyrimidine derivatives
azo dyes
N-(3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-2-aryl hydrazono-3-oxobutanamide derivatives
tetrahydrobenzo[b]thiophene dyes

Synthesis

108-94-1

105-56-6

4506-71-2

GENERAL METHOD: Cyclohexanone (1 mmol), ethyl cyanoacetate (1 eq.), morpholine (1 eq.), and elemental sulfur (1 eq.) were dissolved in 5 mL of ethanol at 0°C and the reaction was stirred overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was extracted three times with ethyl acetate, the organic layers were combined and dried over anhydrous sodium sulfate. After drying, the solvent was again evaporated under reduced pressure. The final product was obtained as purified ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate by recrystallization from a mixed methanol/water solvent as a yellow crystalline solid. Yield: 98%, melting point 134-135 °C. 1H NMR (400 MHz, DMSO-d6) δ 1.20 (3H, t, J = 7.1 Hz, CH3), 1.60-1.65 (4H, m, CH2), 2.35-2.37 (2H, m, CH2), 2.55-2.56 (2H, m, CH2), 4.11 (2H , q, J = 7.3 Hz, OCH2CH3), 7.14 (2H, br s, NH2).13C NMR (100 MHz, DMSO-d6) δ 14.18 (CH3), 22.34 (CH2), 22.76 (CH2), 23.88 (CH2), 26.49 (CH2), 58.71 (OCH2), 103.16 (Cq), 115.96 (Cq), 131.50 (Cq), 163.19 (Cq), 165.32 (C=O).

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 18, p. 4228 - 4240
[2] Synthetic Communications, 2010, vol. 40, # 14, p. 2067 - 2074
[3] European Journal of Medicinal Chemistry, 2016, vol. 122, p. 619 - 634
[4] Journal of Sulfur Chemistry, 2014, vol. 35, # 3, p. 261 - 269
[5] Tetrahedron Letters, 2007, vol. 48, # 18, p. 3171 - 3172

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Sulfur Piperidine Cyclohexanone Ethyl cyanoacetate

Preparation Products

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ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 4506-71-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 4506-71-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

4506-71-2, ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATERelated Search:

ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE 2,5-Dithienylpyrrole 3,5-Dibromodithieno[3,2-b:2',3'-d]thiophene 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER ETHYL 3-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-2-CARBOXYLATE,3-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER 1-Benzothiophene-3-carboxylic acid

TIMTEC-BB SBB000654

Ethyl-2-Amino-4,5,6,7-Tetrahydrobenzene(B)Thiophene-3-Carboxlate

Ethyl 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate

2-Amino-3-carbethoxy-4,5-tetramethylenethiophene, GC 99%

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl

4,5,6,7-Tetrahydro-2-aminobenzo[b]thiophene-3-carboxylic acid ethyl ester

Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate,97%

Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate,99%

ethyl 2-aminotetrahydrobenzo[b]thiophene-3-carboxylate

Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 97%

{Benzo[b]thiophene-3-carboxylic} acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester

2-Amino-3-carbethoxy-4,5-tetramethylenethiophene 2-Amino-3-ethoxycarbonyl-4,5-tetramethylenethiophene 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic Acid Ethyl Ester

2-Amino-4,5,6,7-tetrahydro-benzothiophene-3-carboxylic acid ethyl ester

Benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester

Et2-N-4,5,6,7-4HBzthiophene carboxylate

Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene-3-carboxylate

105461

3-chloro-N-(3-thiophen-2-yl-5-isoxazolyl)propanamide

1-BENZOTHIOPHENE-3-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-, ETHYL ESTER

2-AMINO-3-ETHOXYCARBONYL-4,5-TETRAMETHYLENETHIOPHENE

2-AMINO-3-ETHOXYCARBONYL-THIENOCYCLOHEXANE

2-AMINO-3-CARBETHOXY-4,5-TETRAMETHYLENETHIOPHENE

2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

ART-CHEM-BB B000472

ASISCHEM N39354

CBI-BB ZERO/004885

ETHYL 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

IFLAB-BB F1386-0048

AKOS BBS-00004584

AKOS MSC-0429

AKOS B000472

AKOS 92528

AKOS BBB/012

EOS-62180

NSC 99005

Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate &gt

Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carb

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ISO 9001：2015 REACH

Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxyl...

4506-71-2 ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

4506-71-2

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