glucagon receptor antagonists-4

Product Name: glucagon receptor antagonists-4
CAS No.: 1393124-08-7
Chemical Name: glucagon receptor antagonists-4
Synonyms: CS-2641;PF6291874;GCGR-IN-17;PF-06291874 >=98% (HPLC);PF-06291874, 10 mM in DMSO;Glucagon Receptor Antagonist 4;lucagon receptor antagonists-4;glucagon receptor antagonists-4;PF06291874;PF-06291874;PF 06291874;PF-06291874(glucagon receptor antagonists-4)
CBNumber: CB03133347
Molecular Formula: C26H28F3N3O4
Formula Weight: 503.51
MOL File: 1393124-08-7.mol

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glucagon receptor antagonists-4 Property

Boiling point:: 675.0±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 50mg/mL; DMSO: 50mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL; Ethanol: 0.5mg/mL
form: A crystalline solid
pka: 4.28±0.10(Predicted)
color: White to off-white
InChIKey: IBDYYOQKQCCSDP-QFIPXVFZSA-N
SMILES: FC(F)(F)c1c[n](nc1)c2c(cc(cc2C)O[C@@H](CCC)c3ccc(cc3)C(=O)NCCC(=O)O)C

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Safety

WGK Germany: WGK 3
HS Code: 2933998090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0356
Product name: PF-06291874
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $102.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0356
Product name: PF-06291874
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $436
Updated: 2025/07/31

Cayman Chemical

Product number: 22164
Product name: Glucagon Receptor Antagonist 4
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22164
Product name: Glucagon Receptor Antagonist 4
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 22164
Product name: Glucagon Receptor Antagonist 4
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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glucagon receptor antagonists-4 Chemical Properties,Usage,Production

Uses

PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing.

Biological Activity

PF-06291874 is an orally active, potent and selective glucagon receptor antagonist. PF-06291874 exhibits a robust glucose reductions in subjects with type 2 diabetes mellitus.

in vivo

PF-06291874 exposure is approximately dose-proportional with a half-life of ～19.7-22.7 h. PF-06291874 has a fast on and off rate. PF-06291874 is highly bound to human plasma protein, with a mean free fraction of ～0.55%^[3].

glucagon receptor antagonists-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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glucagon receptor antagonists-4 Suppliers

China 60 India 1 United States 6 Global 67

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glucagon receptor antagonists-4

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1393124-08-7

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