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MK-2 Inhibitor III

Product Name
MK-2 Inhibitor III
CAS No.
1186648-22-5
Chemical Name
MK-2 Inhibitor III
Synonyms
MK2-IN-3 hydrate;MK-2 Inhibitor III;MK-2 INHIBITOR III (COMPOUND 16);MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem;2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate;2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate;Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
CBNumber
CB03136757
Molecular Formula
C21H18N4O2
Formula Weight
358.4
MOL File
1186648-22-5.mol
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MK-2 Inhibitor III Property

Melting point:
>255°C (dec.)
storage temp. 
+2C to +8C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Pale yellow solid
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15943
Product name
MK2 Inhibitor III
Purity
≥95%
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
15943
Product name
MK2 Inhibitor III
Purity
≥95%
Packaging
1mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
15943
Product name
MK2 Inhibitor III
Purity
≥95%
Packaging
5mg
Price
$225
Updated
2024/03/01
AK Scientific
Product number
3003DC
Product name
MK-2InhibitorIII
Packaging
5mg
Price
$348
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
47746
Product name
MK2InhibitorIII
Packaging
2.5mg
Price
$625
Updated
2021/12/16
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MK-2 Inhibitor III Chemical Properties,Usage,Production

Description

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).

Uses

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).[Cayman Chemical]

MK-2 Inhibitor III Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-2 Inhibitor III Suppliers

China 44 India 1 United States 7 Global 52
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
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China
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3445
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ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
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2853530910@QQ.com
Country
China
ProdList
8012
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6313
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
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58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
9946
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
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58

1186648-22-5, MK-2 Inhibitor IIIRelated Search:


  • MK-2 Inhibitor III
  • 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate
  • MK-2 INHIBITOR III (COMPOUND 16)
  • MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem
  • MK2-IN-3 hydrate
  • 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate
  • Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
  • 1186648-22-5