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LDN 193189 hydrochloride

Product Name
LDN 193189 hydrochloride
CAS No.
1435934-00-1
Chemical Name
LDN 193189 hydrochloride
Synonyms
DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;LDN-193189 2HCl|||DM-3189 2HCl;Viomycin LDN 193189 Dihydrochloride;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride
CBNumber
CB03146321
Molecular Formula
C25H24Cl2N6
Formula Weight
479.40426
MOL File
1435934-00-1.mol
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LDN 193189 hydrochloride Property

storage temp. 
-20°C
solubility 
Soluble in DMSO or in Water (up to 5 mg/ml)
form 
solid
color 
Orange-yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
25mg
Price
$219
Updated
2024/03/01
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
10mg
Price
$100
Updated
2024/03/01
Tocris
Product number
6053
Product name
LDN193189dihydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
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LDN 193189 hydrochloride Chemical Properties,Usage,Production

Description

LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

storage

-20°C

References

1) Yu?et al.?(2008),?BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14?1363 2) Chambers?et al.?(2012),?Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol.?30?715 3) Kreitzer?et al. (2013)?A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells,?2?119 4) Lee?et al.?(2011)?BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res.?71?5194

LDN 193189 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN 193189 hydrochloride Suppliers

China 41 United Kingdom 1 United States 7 USA 1 Global 50
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1435934-00-1, LDN 193189 hydrochlorideRelated Search:

Z-FY-CHO 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Ibandronate sodium monohydrate 20ALPHA-HYDROXYCHOLESTEROL

  • LDN-193189 2HCl
  • LDN 193189 dihydrochloride
  • 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
  • Viomycin LDN 193189 Dihydrochloride
  • DM-3189 2HCl
  • LDN-193189 2HC
  • LDN-193189 (DM3189) 2HCl
  • LDN-193189 2HCl|||DM-3189 2HCl
  • 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride
  • 1435934-00-1