LDN 193189 hydrochloride
- Product Name
- LDN 193189 hydrochloride
- CAS No.
- 1435934-00-1
- Chemical Name
- LDN 193189 hydrochloride
- Synonyms
- DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;LDN-193189 2HCl|||DM-3189 2HCl;Viomycin LDN 193189 Dihydrochloride;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride
- CBNumber
- CB03146321
- Molecular Formula
- C25H24Cl2N6
- Formula Weight
- 479.40426
- MOL File
- 1435934-00-1.mol
LDN 193189 hydrochloride Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO or in Water (up to 5 mg/ml)
- form
- solid
- color
- Orange-yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 25mg
- Price
- $219
- Updated
- 2024/03/01
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 10mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 6053
- Product name
- LDN193189dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $216
- Updated
- 2021/12/16
LDN 193189 hydrochloride Chemical Properties,Usage,Production
Description
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.
storage
-20°C
References
1) Yu?et al.?(2008),?BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14?1363 2) Chambers?et al.?(2012),?Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol.?30?715 3) Kreitzer?et al. (2013)?A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells,?2?119 4) Lee?et al.?(2011)?BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res.?71?5194
LDN 193189 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
LDN 193189 hydrochloride Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38631
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@focusbiomolecules.com
- Country
- United States
- ProdList
- 1284
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80