ChemicalBook > CAS DataBase List > MLS-573151

MLS-573151

Product Name
MLS-573151
CAS No.
10179-57-4
Chemical Name
MLS-573151
Synonyms
MLS-573151;MLS-573151 ，S5996;MLS-573151, 10 mM in DMSO;4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide;Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-;MLS-573151,granulocytes,Inhibitor,Ras,inhibit,MLS-000573151,MLS 000573151,GTPase,MLS 573151,Cdc42,MLS573151,MLS000573151
CBNumber
CB03152689
Molecular Formula
C21H19N3O2S
Formula Weight
377.46
MOL File
10179-57-4.mol
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MLS-573151 Property

storage temp. 
RT
solubility 
Soluble in DMSO (up to 20 mg/ml).
form 
solid
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15269
Product name
MLS-573151
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
15269
Product name
MLS-573151
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
15269
Product name
MLS-573151
Purity
≥98%
Packaging
10mg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
15269
Product name
MLS-573151
Purity
≥98%
Packaging
25mg
Price
$426
Updated
2024/03/01
ChemScene
Product number
CS-0062951
Product name
MLS-573151
Purity
99.74%
Packaging
5mg
Price
$100
Updated
2021/12/16
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MLS-573151 Chemical Properties,Usage,Production

Description

The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.

Uses

The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.[Cayman Chemical]

in vitro

mls-573151 was a specific, cell permeable inhibitor of cdc42 with an ic50 of 2 μm [1]. mls-573151 showed no effect on other gtpases, including the related rho family members rhoa, rac1, and rac2. mls-573151 functioned by blocking the binding of gtp to cdc42 [1]. in marrow-derived mesenchymal stem cells, mls-573151 showed no effect on cell migration [3].

References

[1] ZURAB SURVILADZE . Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay[J]. SLAS Discovery, 2010, 15 1: Pages 10-20. DOI:10.1177/1087057109352240
[2] LIN WANG. Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury[J]. Journal of Cellular Physiology, 2016, 232 1: 110-121. DOI:10.1002/jcp.25395

MLS-573151 Preparation Products And Raw materials

Raw materials

Preparation Products

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MLS-573151 Suppliers

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10179-57-4, MLS-573151Related Search:

1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one Sulindac sulfide THIOSTREPTON EPAC 5376753

  • MLS-573151
  • Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-
  • 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
  • MLS-573151,granulocytes,Inhibitor,Ras,inhibit,MLS-000573151,MLS 000573151,GTPase,MLS 573151,Cdc42,MLS573151,MLS000573151
  • 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide
  • MLS-573151, 10 mM in DMSO
  • MLS-573151 ，S5996
  • 10179-57-4