(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
- Product Name
- (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
- CAS No.
- 116195-15-4
- Chemical Name
- (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
- Synonyms
- (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam;2-Propen-1-one, 2-methyl-1-[(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-
- CBNumber
- CB03161933
- Molecular Formula
- C14H21NO3S
- Formula Weight
- 283.39
- MOL File
- 116195-15-4.mol
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Property
- Melting point:
- 145 °C
- Boiling point:
- 397.5±25.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -14.95±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4356CS
- Product name
- (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 4356CS
- Product name
- (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
- Packaging
- 5g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- CM247929
- Product name
- 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-2-methylprop-2-en-1-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $449
- Updated
- 2021/12/16
- Product number
- A544363
- Product name
- (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
- Purity
- 97%
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CM247929
- Product name
- 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-2-methylprop-2-en-1-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Chemical Properties,Usage,Production
Synthesis
94594-90-8
920-46-7
116195-15-4
Example 2: Synthesis of (R)-5-methyl-4,5-dihydro-pyrazole-1,5-dicarboxylic acid 1-[(4-chloro-phenyl)-amido]5-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amido} Step 1. Synthesis of (3aS,6R,7aR)-1-methacryloyl-8,8-dimethylhexahydro-3a,6-methylene-2,1-benzisothiazole-2,2-dioxide (1S)-(-)-2,10-camphorsulfonate To a solution of (1S)-(-)-2,10-camphorsulfonamide (1.160 g, 5.388 mmol) in toluene (10 ml) was added sodium hydride (60% oil, 0.323 g, 8.08 mmol). After stirring for 1.5 h, methacryloyl chloride (1.126 g, 10.78 mmol) was added directly to the reaction mixture. The mixture was stirred overnight at room temperature, followed by evaporation of the solvent. The residue was extracted into ethyl acetate, washed with 1N HCl, dried with MgSO4, evaporated in vacuum and purified by chromatography (0-20% EtOAc in hexane solution) to afford the target compound (1.240 g, 81%). 1H NMR (400MHz, DMSO-D6) δ ppm: 0.90 (s, 3H), 1.08 (s, 3H), 1.23 (m, 1H), 1.42 (m, 1H), 1.78 (m, 5H), 1.81 (m, 3H), 3.26 (s, 4H), 3.56 (d, J = 14.04Hz, 1H), 3.77 (d , J = 14.04Hz, 1H), 3.91 (m, 1H), 5.48 (s, 1H), 5.60 (s, 1H).
References
[1] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3218 - 3227
[2] Patent: WO2008/65503, 2008, A1. Location in patent: Page/Page column 36
[3] Tetrahedron Asymmetry, 1991, vol. 2, # 12, p. 1359 - 1370
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam manufacturers
- Product
- ((R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam 116195-15-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-20