ChemicalBook > CAS DataBase List > Pimodivir

Pimodivir

Product Name
Pimodivir
CAS No.
1629869-44-8
Chemical Name
Pimodivir
Synonyms
VX-787;CS-2483;Pimodivir;VRT0928787;VRT-0928787;VRT 0928787;JNJ63623872;JNJ 63623872;JNJ-63623872;Pimodivir (VX-787)
CBNumber
CB03169595
Molecular Formula
C20H19F2N5O2
Formula Weight
399.39
MOL File
1629869-44-8.mol
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Pimodivir Property

Density 
1.501±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
form 
A solid
pka
4.32±0.40(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29321
Product name
Pimodivir
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29321
Product name
Pimodivir
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
29321
Product name
Pimodivir
Packaging
10mg
Price
$146
Updated
2024/03/01
TRC
Product number
P447815
Product name
Pimodivir
Packaging
10mg
Price
$140
Updated
2021/12/16
ChemScene
Product number
CS-6423
Product name
Pimodivir
Purity
99.45%
Packaging
10mg
Price
$150
Updated
2021/12/16
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Pimodivir Chemical Properties,Usage,Production

Description

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; Ki = ~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

Uses

Pimodivir is an orally bioavailable azaindole inhibitor of influenza PB2.

Pimodivir Preparation Products And Raw materials

Raw materials

Preparation Products

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Pimodivir Suppliers

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1629869-44-8, PimodivirRelated Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide AVN-944 VE 822 Telaprevir VX-770

  • Pimodivir
  • Pimodivir (VX-787)
  • VX-787
  • (2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]bicyclo[2.2.2]octane-2-carboxylic acid
  • CS-2483
  • VRT 0928787
  • VRT0928787
  • VRT-0928787
  • VX-787; VX 787; VX787; JNJ-872; JNJ 872; JNJ872; VRT-0928787; VRT 0928787; VRT0928787;PIMODIVIR
  • VX-787 (Pimodivir)
  • Bicyclo[2.2.2]octane-2-carboxylic acid, 3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-, (2S,3S)-
  • Influenza Virus,Inhibitor,inhibit,VX787,Pimodivir,VX 787
  • JNJ 63623872
  • JNJ63623872
  • JNJ-63623872
  • 1629869-44-8