ChemicalBook > CAS DataBase List > Pimodivir

Pimodivir

Product Name: Pimodivir
CAS No.: 1629869-44-8
Chemical Name: Pimodivir
Synonyms: VX-787;CS-2483;Pimodivir;VRT0928787;VRT-0928787;VRT 0928787;JNJ63623872;JNJ 63623872;JNJ-63623872;Pimodivir (VX-787)
CBNumber: CB03169595
Molecular Formula: C20H19F2N5O2
Formula Weight: 399.39
MOL File: 1629869-44-8.mol

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Pimodivir Property

Density: 1.501±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
form: A solid
pka: 4.32±0.40(Predicted)
color: White to light yellow
InChIKey: JGPXDNKSIXAZEQ-SBBZOCNPSA-N
SMILES: C12CCC(CC1)[C@H](NC1C(F)=CN=C(C3C4=CC(F)=CN=C4NC=3)N=1)[C@H]2C(O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29321
Product name: Pimodivir
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29321
Product name: Pimodivir
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 29321
Product name: Pimodivir
Packaging: 10mg
Price: $146
Updated: 2024/03/01

TRC

Product number: P447815
Product name: Pimodivir
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-6423
Product name: Pimodivir
Purity: 99.45%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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Pimodivir Chemical Properties,Usage,Production

Description

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; K_D = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; K_i = ^~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC₅₀s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI₅₀) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

Uses

Pimodivir is an orally bioavailable azaindole inhibitor of influenza PB2.

in vivo

Pimodivir (2, 6, and 20 mg/kg/day, p.o.) and GS 4071 (20 mg/kg/day) completely prevent death in the H1N1pdm virus infection in mice. Pimodivir (20 mg/kg/day) is more effective than GS 4071 (20 mg/kg/day) in improving body weight and reducing the severity of lung infection^[1].
Moreover, Pimodivir (VX-787) shows 100% survival in a +48 h delay to treatment mouse influenza model at 10, 3 and 1 mpk (BID × 10 days) whereas the SOC, GS 4071, provide no survival benefit in this model at 10 mpk^[3].
Pimodivir (VX-787; 1, 3, or 10 mg/kg, bid) provided complete survival, with a dose-dependent reduction in BW loss of the mice^[4].

References

[1] MICHAEL P. CLARK*. Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2[J]. Journal of Medicinal Chemistry, 2014, 57 15: 6668-6678. DOI: 10.1021/jm5007275
[2] RANDAL A BYRN. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit.[J]. Antimicrobial Agents and Chemotherapy, 2015: 1569-1582. DOI: 10.1128/aac.04623-14

Pimodivir Preparation Products And Raw materials

Raw materials

Preparation Products

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1629869-44-8, PimodivirRelated Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide AVN-944 VE 822 Telaprevir VX-770

Pimodivir

Pimodivir (VX-787)

VX-787

(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]bicyclo[2.2.2]octane-2-carboxylic acid

CS-2483

VRT 0928787

VRT0928787

VRT-0928787

VX-787; VX 787; VX787; JNJ-872; JNJ 872; JNJ872; VRT-0928787; VRT 0928787; VRT0928787;PIMODIVIR

VX-787 (Pimodivir)

Bicyclo[2.2.2]octane-2-carboxylic acid, 3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-, (2S,3S)-

Influenza Virus,Inhibitor,inhibit,VX787,Pimodivir,VX 787

JNJ 63623872

JNJ63623872

JNJ-63623872

Pimodivir, 10 mM in DMSO

1629869-44-8