Pimodivir
- Product Name
- Pimodivir
- CAS No.
- 1629869-44-8
- Chemical Name
- Pimodivir
- Synonyms
- VX-787;CS-2483;Pimodivir;VRT0928787;VRT-0928787;VRT 0928787;JNJ63623872;JNJ 63623872;JNJ-63623872;Pimodivir (VX-787)
- CBNumber
- CB03169595
- Molecular Formula
- C20H19F2N5O2
- Formula Weight
- 399.39
- MOL File
- 1629869-44-8.mol
Pimodivir Property
- Density
- 1.501±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
- form
- A solid
- pka
- 4.32±0.40(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29321
- Product name
- Pimodivir
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29321
- Product name
- Pimodivir
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 29321
- Product name
- Pimodivir
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- P447815
- Product name
- Pimodivir
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-6423
- Product name
- Pimodivir
- Purity
- 99.45%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
Pimodivir Chemical Properties,Usage,Production
Description
Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; Ki = ~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.
Uses
Pimodivir is an orally bioavailable azaindole inhibitor of influenza PB2.
Pimodivir Preparation Products And Raw materials
Raw materials
Preparation Products
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