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6-HYDROXYDOPAMINE HYDROCHLORIDE

Product Name
6-HYDROXYDOPAMINE HYDROCHLORIDE
CAS No.
28094-15-7
Chemical Name
6-HYDROXYDOPAMINE HYDROCHLORIDE
Synonyms
6-OHDA;6-Hd HCl;Nsc233898;OxydopaMine HCL;TIMTEC-BB SBB003496;6-OHDA hydrochloride;6-Hydroxydopamine hy;TopaMine Hydrochloride;OxidopaMine Hydrochloride;6-hydroxydopaminechloride
CBNumber
CB0320270
Molecular Formula
C8H12ClNO3
Formula Weight
205.64
MOL File
28094-15-7.mol
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6-HYDROXYDOPAMINE HYDROCHLORIDE Property

Melting point:
232-233 °C (dec.)(lit.)
storage temp. 
room temp
solubility 
H2O: >50 mg/mL, clear, yellow to brown
form 
powder
color 
off-white to brown
BRN 
4274007
InChI
InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChIKey
QLMRJHFAGVFUAC-UHFFFAOYSA-N
SMILES
C1(CCN)=CC(=C(O)C=C1O)O.Cl
EPA Substance Registry System
6-Hydroxydopamine hydrochloride (28094-15-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DC4650000
3-8-10-23
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H4381
Product name
6-Hydroxydopamine hydrochloride
Purity
≥97% (titration), powder
Packaging
100mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
H4381
Product name
6-Hydroxydopamine hydrochloride
Purity
≥97% (titration), powder
Packaging
1g
Price
$850
Updated
2024/03/01
Sigma-Aldrich
Product number
H4381
Product name
6-Hydroxydopamine hydrochloride
Purity
≥97% (titration), powder
Packaging
500mg
Price
$554
Updated
2024/03/01
TRC
Product number
H941743
Product name
6-Hydroxydopamine hydrochloride
Packaging
10mg
Price
$55
Updated
2021/12/16
TRC
Product number
H941743
Product name
6-Hydroxydopamine hydrochloride
Packaging
50mg
Price
$165
Updated
2021/12/16
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6-HYDROXYDOPAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.

Uses

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Uses

6-hydroxydopamine hydrochloride has been used:

  • to induce Parkinson′s disease (PD) in rats
  • to analyse cytotoxic effect of 6-OHDA on PC12 cell line
  • to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

General Description

Beige solid.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.

Fire Hazard

Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Biochem/physiol Actions

Neurotoxin that destroys catecholaminergic terminals.

Mechanism of action

The biochemical mechanism of toxicity of 6-Hydroxydopamine hydrochloride (6-OHDA) is as follows: 6-OHDA has two modes of action: it readily forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive to free radical scavengers and iron chelators, except for desferrioxamine. Moreover, free radicals are not involved in the interaction between 6-OHDA and the respiratory chain, and the two mechanisms are biochemically independent, although they may act synergistically in vivo.

6-HYDROXYDOPAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-HYDROXYDOPAMINE HYDROCHLORIDE Suppliers

Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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4660
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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TargetMol Chemicals Inc.
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Aladdin Scientific
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TimTec Corporation
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Spectrum Chemicals & Laboratory Products
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View Lastest Price from 6-HYDROXYDOPAMINE HYDROCHLORIDE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-20
Hebei Mojin Biotechnology Co., Ltd
Product
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Career Henan Chemical Co
Product
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

28094-15-7, 6-HYDROXYDOPAMINE HYDROCHLORIDERelated Search:


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  • 6-OHDA hydrochloride
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  • Neuro-2a cells,p-p38,Interleukin Related,p38 MAPK,PC12 cells,Apoptosis,Dopamine Receptor,Mitophagy,neurotoxicity,Autophagy,Oxidopamine hydrochloride,6-OHDA,Prostaglandin E synthase,Cyclooxygenase,Lesch-Nyhan syndrome,inhibit,Mitochondrial Autophagy,PGE2,attention-deficit hyperactivity disorder,Parkinson’s disease,SH-SY5Y cells,Oxidopamine,Caspase,PGE synthase,Inhibitor,COX,6-Hydroxydopamine
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