ChemicalBook > CAS DataBase List > 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- Product Name
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- CAS No.
- 1147-56-4
- Chemical Name
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- Synonyms
- TAN;ERGi-USU;NSC139021;Nitrilotantalum(III);NSC139021 (ERGi-USU);ERGi-USU (NSC139021);1-(2’-Thiazolylazo)-β-naphtho;1-(2-THIAZOLYLAZO)-2-NAPHTHOL;1-(thiazol-2-ylazo)-2-naphthol;1-(2'-Thiazolylazo)-β-naphthol
- CBNumber
- CB0321974
- Molecular Formula
- C13H9N3OS
- Formula Weight
- 255.3
- MOL File
- 1147-56-4.mol
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Property
- Melting point:
- 138-139 °C
- Boiling point:
- 464.8±47.0 °C(Predicted)
- Density
- 1.40
- storage temp.
- 2-8°C
- solubility
- methanol: 10 mg/mL, clear
- pka
- 8.71±0.50(Predicted)
- form
- solid
- color
- Red or orange
- BRN
- 223783
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- CAS DataBase Reference
- 1147-56-4(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- A5003
- Product name
- TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
- Purity
- >99.0%(T)
- Packaging
- 1g
- Price
- $72
- Updated
- 2024/03/01
TCI Chemical
- Product number
- A5003
- Product name
- TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $246
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- B24011
- Product name
- 1-(2-Thiazolylazo)-2-naphthol, 98%
- Packaging
- 1g
- Price
- $32.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- B24011
- Product name
- 1-(2-Thiazolylazo)-2-naphthol, 98%
- Packaging
- 5g
- Price
- $103.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- B24011
- Product name
- 1-(2-Thiazolylazo)-2-naphthol, 98%
- Packaging
- 25g
- Price
- $409.65
- Updated
- 2024/03/01
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties,Usage,Production
Description
ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
Uses
1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
storage
Store at +4°C
References
1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Preparation Products And Raw materials
Raw materials
Preparation Products
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Suppliers
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View Lastest Price from 1-(2-THIAZOLYLAZO)-2-NAPHTHOL manufacturers
Qingdao RENAS Polymer Material Co., Ltd.
- Product
- 1-(2-Thiazolylazo)-2-naphthol 1147-56-4
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-01
Shaanxi Dideu Medichem Co. Ltd
- Product
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL 1147-56-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-16
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL 1147-56-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL