1-(2-THIAZOLYLAZO)-2-NAPHTHOL

ChemicalBook > CAS DataBase List > 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

1-(2-THIAZOLYLAZO)-2-NAPHTHOL

Product Name: 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
CAS No.: 1147-56-4
Chemical Name: 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
Synonyms: TAN;ERGi-USU;NSC139021;Nitrilotantalum(III);NSC139021 (ERGi-USU);ERGi-USU (NSC139021);1-(2’-Thiazolylazo)-β-naphtho;1-(2-THIAZOLYLAZO)-2-NAPHTHOL;1-(thiazol-2-ylazo)-2-naphthol;1-(2'-Thiazolylazo)-β-naphthol
CBNumber: CB0321974
Molecular Formula: C13H9N3OS
Formula Weight: 255.3
MOL File: 1147-56-4.mol

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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Property

Melting point:: 138-139 °C
Boiling point:: 464.8±47.0 °C(Predicted)
Density: 1.40
storage temp.: 2-8°C
solubility: methanol: 10 mg/mL, clear
pka: 8.71±0.50(Predicted)
form: solid
color: Red or orange
BRN: 223783
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference: 1147-56-4(CAS DataBase Reference)
EPA Substance Registry System: 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4)

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 2927.00.5000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A5003
Product name: TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
Purity: >99.0%(T)
Packaging: 1g
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: A5003
Product name: TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
Purity: >99.0%(T)
Packaging: 5g
Price: $246
Updated: 2024/03/01

Alfa Aesar

Product number: B24011
Product name: 1-(2-Thiazolylazo)-2-naphthol, 98%
Packaging: 1g
Price: $32.65
Updated: 2024/03/01

Alfa Aesar

Product number: B24011
Product name: 1-(2-Thiazolylazo)-2-naphthol, 98%
Packaging: 5g
Price: $103.65
Updated: 2024/03/01

Alfa Aesar

Product number: B24011
Product name: 1-(2-Thiazolylazo)-2-naphthol, 98%
Packaging: 25g
Price: $409.65
Updated: 2024/03/01

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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties,Usage,Production

Description

ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.

Uses

1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

storage

Store at +4°C

References

1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659

1-(2-THIAZOLYLAZO)-2-NAPHTHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Suppliers

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View Lastest Price from 1-(2-THIAZOLYLAZO)-2-NAPHTHOL manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 1-(2-Thiazolylazo)-2-naphthol 1147-56-4
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-01

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(2-THIAZOLYLAZO)-2-NAPHTHOL 1147-56-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(2-THIAZOLYLAZO)-2-NAPHTHOL 1147-56-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

1147-56-4, 1-(2-THIAZOLYLAZO)-2-NAPHTHOLRelated Search:

LFM-A13 (+)-Camptothecin Brefeldin A SU 4312 2-Methyl-4-isothiazolin-3-one TPPS 1-[4-(1-Adamantyl)-2-thiazolylazo]-2-naphthol 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

TAN

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1-(Thiazole-2-ylazo)-2-naphthol

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(1Z)-1-(2-thiazolylhydrazinylidene)-2-naphthalenone

ERGi-USU (NSC139021)

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1-(2’-Thiazolylazo)-β-naphtho

1-(2-thiazolylazo)-2-naphthaleno

1-(2-thiazolylazo)-2-Naphthalenol

2-(2-HYDROXY-1-NAPHTHYLAZO)THIAZOLE

1-(2-THIAZOLYLAZO)-2-NAPHTHOL

1-(thiazol-2-ylazo)-2-naphthol

1-(2'-Thiazolylazo)-β-naphthol

TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]&gt

2-Naphthalenol, 1-[2-(2-thiazolyl)diazenyl]-

NSC139021 (ERGi-USU)

inhibit,NSC 139021,NSC-139021,NSC139021,Inhibitor

1147-56-4

147-56-4

IR/UV/ VIS

Analytical Chromatography Product Catalog

Analytical Reagents

Azo Compounds

Naphthylazo Compounds

Chelating Reagents

Spectroscopy Reagents

Analytical Chemistry

Azo Compounds

Chelating Reagents

Naphthylazo Compounds