ChemicalBook > CAS DataBase List > 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

1-(2-THIAZOLYLAZO)-2-NAPHTHOL

Product Name
1-(2-THIAZOLYLAZO)-2-NAPHTHOL
CAS No.
1147-56-4
Chemical Name
1-(2-THIAZOLYLAZO)-2-NAPHTHOL
Synonyms
TAN;ERGi-USU;NSC139021;Nitrilotantalum(III);NSC139021 (ERGi-USU);ERGi-USU (NSC139021);1-(2’-Thiazolylazo)-β-naphtho;1-(2-THIAZOLYLAZO)-2-NAPHTHOL;1-(thiazol-2-ylazo)-2-naphthol;1-(2'-Thiazolylazo)-β-naphthol
CBNumber
CB0321974
Molecular Formula
C13H9N3OS
Formula Weight
255.3
MOL File
1147-56-4.mol
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Property

Melting point:
138-139 °C
Boiling point:
464.8±47.0 °C(Predicted)
Density 
1.40
storage temp. 
2-8°C
solubility 
methanol: 10 mg/mL, clear
pka
8.71±0.50(Predicted)
form 
solid
color 
Red or orange
BRN 
223783
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference
1147-56-4(CAS DataBase Reference)
EPA Substance Registry System
2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4)
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Safety

Risk Statements 
36/37/38
Safety Statements 
22-24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
2927.00.5000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A5003
Product name
TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
Purity
>99.0%(T)
Packaging
1g
Price
$72
Updated
2024/03/01
TCI Chemical
Product number
A5003
Product name
TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
Purity
>99.0%(T)
Packaging
5g
Price
$246
Updated
2024/03/01
Alfa Aesar
Product number
B24011
Product name
1-(2-Thiazolylazo)-2-naphthol, 98%
Packaging
1g
Price
$32.65
Updated
2024/03/01
Alfa Aesar
Product number
B24011
Product name
1-(2-Thiazolylazo)-2-naphthol, 98%
Packaging
5g
Price
$103.65
Updated
2024/03/01
Alfa Aesar
Product number
B24011
Product name
1-(2-Thiazolylazo)-2-naphthol, 98%
Packaging
25g
Price
$409.65
Updated
2024/03/01
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties,Usage,Production

Description

ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.

Uses

1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

storage

Store at +4°C

References

1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659

1-(2-THIAZOLYLAZO)-2-NAPHTHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-THIAZOLYLAZO)-2-NAPHTHOL Suppliers

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View Lastest Price from 1-(2-THIAZOLYLAZO)-2-NAPHTHOL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(2-THIAZOLYLAZO)-2-NAPHTHOL 1147-56-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals] 1147-56-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
1-(2-THIAZOLYLAZO)-2-NAPHTHOL 1147-56-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-08

1147-56-4, 1-(2-THIAZOLYLAZO)-2-NAPHTHOLRelated Search:

LFM-A13 (+)-Camptothecin Brefeldin A SU 4312 2-Methyl-4-isothiazolin-3-one TPPS 1-[4-(1-Adamantyl)-2-thiazolylazo]-2-naphthol 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

  • TAN
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  • 2-(2-HYDROXY-1-NAPHTHYLAZO)THIAZOLE
  • 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
  • 1-(thiazol-2-ylazo)-2-naphthol
  • 1-(2'-Thiazolylazo)-β-naphthol
  • TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]&gt
  • 2-Naphthalenol, 1-[2-(2-thiazolyl)diazenyl]-
  • NSC139021 (ERGi-USU)
  • inhibit,NSC 139021,NSC-139021,NSC139021,Inhibitor
  • 1147-56-4
  • 147-56-4
  • IR/UV/ VIS
  • Analytical Chromatography Product Catalog
  • Analytical Reagents
  • Azo Compounds
  • Naphthylazo Compounds
  • Chelating Reagents
  • Spectroscopy Reagents
  • Analytical Chemistry
  • Azo Compounds
  • Chelating Reagents
  • Naphthylazo Compounds