ChemicalBook > CAS DataBase List > NS-2028

NS-2028

Product Name: NS-2028
CAS No.: 204326-43-2
Chemical Name: NS-2028
Synonyms: NS-2028;NS-2028, 10 mM in DMSO;NS 2028 - CAS 204326-43-2 - Calbiochem;4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE;NS 2028,inhibit,Inhibitor,NS-2028,NS2028,Guanylate Cyclase;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE;8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one;8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One;1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-
CBNumber: CB0326227
Molecular Formula: C9H5BrN2O3
Formula Weight: 269.05
MOL File: 204326-43-2.mol

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NS-2028 Property

Melting point:: 160～170℃
Boiling point:: 353.8±52.0 °C(Predicted)
Density: 2.06±0.1 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: DMSO: 13 mg/mL
form: solid
pka: -1.18±0.20(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 492030
Product name: NS 2028
Packaging: 5mg
Price: $327
Updated: 2025/07/31

Sigma-Aldrich

Product number: N211
Product name: NS 2028
Purity: solid
Packaging: 5mg
Price: $267
Updated: 2022/05/15

Cayman Chemical

Product number: 81600
Product name: NS 2028
Purity: ≥98%
Packaging: 1mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 81600
Product name: NS 2028
Purity: ≥98%
Packaging: 5mg
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: N211
Product name: NS 2028
Purity: solid
Packaging: 25mg
Price: $1060
Updated: 2022/05/15

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NS-2028 Chemical Properties,Usage,Production

Uses

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

Uses

NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Biological Activity

Cell permeable: no', 'Primary Target
basal soluble guanylyl cyclase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum

in vivo

NS-2028 (Deliver orally; 1 g/L; 8 days) exhibits a significant reduction of new vessel formation in the avascular rabbit cornea in response to VEGF pellet implants^[2].

Animal Model:	Rabbit^[2]
Dosage:	1 g/L
Administration:	Deliver orally; 1g/L; 8 days
Result:	Inhibits VEGF-induced angiogenesis in vivo.

storage

Store at +4°C

NS-2028 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS-2028 Suppliers

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View Lastest Price from NS-2028 manufacturers

Career Henan Chemical Co

Product: NS-2028 204326-43-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-18

204326-43-2, NS-2028Related Search:

BAY 41-2272 GUANYLIN (HUMAN) ODQ TYRPHOSTIN AG 1288 YC-1 GUANYLIN (RAT) Protoporphyrin IX L-Carnosine 6-ANILINO-5,8-QUINOLINEDIONE 6-Bromo-4-methyl-3,4-dihydro-2H-1,4-benzoxazine NS-2028 2-(4-bromophenoxy)ethanimidamide 5-BROMO-2-METHOXYANILINE 3-BROMO-N,N-DIMETHYLANILINE

NS-2028

8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE

4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE

4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE

4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE

NS 2028 - CAS 204326-43-2 - Calbiochem

8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One

8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-

8-Bromo-1H,4H-benzo[b][1,2,4]oxadiazolo[4,3-d][1,4]oxazin-1-one

NS 2028,inhibit,Inhibitor,NS-2028,NS2028,Guanylate Cyclase

NS-2028, 10 mM in DMSO

204326-43-2

C9H5BrN2O3

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Cyclic Nucleotide Metabolism

Guanylyl Cyclase Inhibitors

G Proteins and Cyclic Nucleotides

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals