ChemicalBook > CAS DataBase List > NS-2028

NS-2028

Product Name
NS-2028
CAS No.
204326-43-2
Chemical Name
NS-2028
Synonyms
NS-2028;NS 2028 - CAS 204326-43-2 - Calbiochem;4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE;NS 2028,inhibit,Inhibitor,NS-2028,NS2028,Guanylate Cyclase;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE;8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one;8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One;1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-;8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE
CBNumber
CB0326227
Molecular Formula
C9H5BrN2O3
Formula Weight
269.05
MOL File
204326-43-2.mol
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NS-2028 Property

Melting point:
160～170℃
Boiling point:
353.8±52.0 °C(Predicted)
Density 
2.06±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMSO: 13 mg/mL
form 
solid
pka
-1.18±0.20(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
492030
Product name
NS 2028
Packaging
5mg
Price
$318
Updated
2024/03/01
Sigma-Aldrich
Product number
N211
Product name
NS 2028
Purity
solid
Packaging
5mg
Price
$267
Updated
2022/05/15
Cayman Chemical
Product number
81600
Product name
NS 2028
Purity
≥98%
Packaging
1mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
81600
Product name
NS 2028
Purity
≥98%
Packaging
5mg
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
N211
Product name
NS 2028
Purity
solid
Packaging
25mg
Price
$1060
Updated
2022/05/15
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NS-2028 Chemical Properties,Usage,Production

Uses

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

Uses

NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

storage

Store at +4°C

NS-2028 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS-2028 Suppliers

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View Lastest Price from NS-2028 manufacturers

Career Henan Chemical Co
Product
NS-2028 204326-43-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

204326-43-2, NS-2028Related Search:

BAY 41-2272 GUANYLIN (HUMAN) ODQ TYRPHOSTIN AG 1288 YC-1 GUANYLIN (RAT) Protoporphyrin IX L-Carnosine 6-ANILINO-5,8-QUINOLINEDIONE 6-Bromo-4-methyl-3,4-dihydro-2H-1,4-benzoxazine NS-2028 2-(4-bromophenoxy)ethanimidamide 5-BROMO-2-METHOXYANILINE 3-BROMO-N,N-DIMETHYLANILINE

  • NS-2028
  • 8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE
  • 4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE
  • 4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE
  • 4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE
  • NS 2028 - CAS 204326-43-2 - Calbiochem
  • 8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One
  • 8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
  • 1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-
  • 8-Bromo-1H,4H-benzo[b][1,2,4]oxadiazolo[4,3-d][1,4]oxazin-1-one
  • NS 2028,inhibit,Inhibitor,NS-2028,NS2028,Guanylate Cyclase
  • 204326-43-2
  • C9H5BrN2O3
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Cyclic Nucleotide Metabolism
  • Guanylyl Cyclase Inhibitors
  • G Proteins and Cyclic Nucleotides
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals