ChemicalBook > CAS DataBase List > Saikosaponin D

Saikosaponin D

Product Name: Saikosaponin D
CAS No.: 20874-52-6
Chemical Name: Saikosaponin D
Synonyms: Saikoside d;saikosaponin;saikosaponins;SAIKOSAPONIN D;SAILKOSAPONIN D;Saikosaponian D;SAILKOSAPONINS D;Saikosaponin D(P);Saikosaponin D-RM;SAIKOSAPONIN D(RG)
CBNumber: CB0329374
Molecular Formula: C42H68O13
Formula Weight: 780.99
MOL File: 20874-52-6.mol

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Saikosaponin D Property

Melting point:: 212～218℃
Boiling point:: 893.7±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, Refrigerator, Under inert atmosphere
solubility: Methanol (Slightly), Pyridine (Slightly)
form: Solid
pka: 12.83±0.70(Predicted)
color: White to Off-White
Stability:: Hygroscopic
InChIKey: KYWSCMDFVARMPN-LPVIBIOGNA-N
LogP: 3.756 (est)
CAS DataBase Reference: 20874-52-6

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Safety

Safety Statements: 24/25
RTECS: VN3099000
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3405
Product name: Saikosaponin D
Packaging: 10MG
Price: $94
Updated: 2025/07/31

TCI Chemical

Product number: A3405
Product name: Saikosaponin D
Packaging: 50MG
Price: $284
Updated: 2025/07/31

TRC

Product number: S083915
Product name: SaikosaponinD
Packaging: 2.5mg
Price: $50
Updated: 2021/12/16

TRC

Product number: S083915
Product name: SaikosaponinD
Packaging: 10mg
Price: $80
Updated: 2021/12/16

Usbiological

Product number: 297731
Product name: Saikosaponin D
Packaging: 5mg
Price: $319
Updated: 2021/12/16

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Saikosaponin D Chemical Properties,Usage,Production

Description

Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.

Chemical Properties

Pale yellow crystals, easily soluble in water and dilute alcohol, difficult to dissolve in benzene, ether and chloroform, derived from the aerial parts of Bupleurum chinense.

Uses

Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.

Uses

Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.

Biological Activity

Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.

in vivo

Saikosaponin D (2 mg/kg/day, i.p.) shows a protective effect on overdose of acetaminophen (APAP)-induced liver injury of mice. Saikosaponin D affects APAP metabolism, increases GSH levels but does not alter PPARα activation. Saikosaponin D (2 mg/kg/day, i.p.) also suppresses APAP-induced increases in the expression of STAT3 target genes and pro-inflammatory cytokines and inhibits APAP-induced activation of STAT3 and NF-kB^[2].

IC 50

STAT3; NF-κB; ERβ

Clinical claims and research

We have previously identified a small-molecule, saikosaponin-d (Ssd), that exhibits anti-inflammatory effect via the suppression of NF-κB, NF-AT and AP-1 signaling. We recently showed that Ssd potentiated the anti-cancer potency of TNF-α through NF-κB inhibition. Ssd is one of the major triterpenoid saponins derived from Bupleurum falcatum L. (Umbelliferae), which is commonly prescribed for inflammatory and infectious diseases, and its active component Ssd was reported to have immuno-modulatory, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer activities.

Saikosaponin D Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Saikosaponin D manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Saikosaponin D 20874-52-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%; 98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-14

Shaanxi Haibo Biotechnology Co., Ltd

Product: Saikosaponin D 20874-52-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

Shanghai Standard Technology Co., Ltd.

Product: Saikosaponin D 20874-52-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-29

20874-52-6, Saikosaponin DRelated Search:

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SAIKOSAPONIN D

Saikosaponin D, 98%, from Bupleurum chinense DC.

saikosaponin

saikosaponins

Saikosaponian D

SAIKOSAPONIN D 98+% BY HPLC

SAILKOSAPONINS D

Saikosaponin d std.

SAILKOSAPONIN D

SAIKOSAPONIN D(RG)

Saikoside d

SAIKOSAPONIN B2(P)

Saikosaponin D 20874-52-6

b-D-Galactopyranoside, (3b,4a,16a)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-b-D-glucopyranosyl-

Bupleurum saikosaponin D

β-D-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Saikosaponin D(P)

Saikosaponin D-RM

Saikosaponin D, 10 mM in DMSO

SAIKOSAPONIAN D ,98+%

20874-52-6

20736-52-6

C48H78O18

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Aromatic Phenols