Saikosaponin D
- Product Name
- Saikosaponin D
- CAS No.
- 20874-52-6
- Chemical Name
- Saikosaponin D
- Synonyms
- Saikoside d;saikosaponin;saikosaponins;SAIKOSAPONIN D;SAILKOSAPONIN D;Saikosaponian D;SAILKOSAPONINS D;Saikosaponin D(P);Saikosaponin D-RM;SAIKOSAPONIN D(RG)
- CBNumber
- CB0329374
- Molecular Formula
- C42H68O13
- Formula Weight
- 780.99
- MOL File
- 20874-52-6.mol
Saikosaponin D Property
- Melting point:
- 212～218℃
- Boiling point:
- 893.7±65.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, Under inert atmosphere
- solubility
- Methanol (Slightly), Pyridine (Slightly)
- form
- Solid
- pka
- 12.83±0.70(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- LogP
- 3.756 (est)
- CAS DataBase Reference
- 20874-52-6
Safety
- Safety Statements
- 24/25
- RTECS
- VN3099000
- HS Code
- 29389090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- S083915
- Product name
- SaikosaponinD
- Packaging
- 2.5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- S083915
- Product name
- SaikosaponinD
- Packaging
- 10mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 297731
- Product name
- Saikosaponin D
- Packaging
- 5mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- 300910
- Product name
- Saikosaponin D
- Packaging
- 20mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- OS09508
- Product name
- Saikosaponin D
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
Saikosaponin D Chemical Properties,Usage,Production
Description
Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.
Uses
Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.
Uses
Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.
Biological Activity
Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.
Clinical claims and research
We have previously identified a small-molecule, saikosaponin-d (Ssd), that exhibits anti-inflammatory effect via the suppression of NF-κB, NF-AT and AP-1 signaling. We recently showed that Ssd potentiated the anti-cancer potency of TNF-α through NF-κB inhibition. Ssd is one of the major triterpenoid saponins derived from Bupleurum falcatum L. (Umbelliferae), which is commonly prescribed for inflammatory and infectious diseases, and its active component Ssd was reported to have immuno-modulatory, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer activities.
Saikosaponin D Preparation Products And Raw materials
Raw materials
Preparation Products
Saikosaponin D Suppliers
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80
- Tel
- --
- Fax
- --
- info-tech@nacalai.co.jp
- Country
- Japan
- ProdList
- 6046
- Advantage
- 75
View Lastest Price from Saikosaponin D manufacturers
- Product
- Saikosaponin D 20874-52-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 95%; 98% HPLC
- Supply Ability
- 1000kg
- Release date
- 2022-10-14
- Product
- Saikosaponin D 20874-52-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000ton
- Release date
- 2023-08-21
- Product
- Saikosaponin D 20874-52-6
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-09-29