TETRAHYDRO-3-FURANMETHANOL
Uses- Product Name
- TETRAHYDRO-3-FURANMETHANOL
- CAS No.
- 15833-61-1
- Chemical Name
- TETRAHYDRO-3-FURANMETHANOL
- Synonyms
- (TETRAHYDROFURAN-3-YL)METHANOL;3-tetrahydrofuranmethanol;3-Hydroxymethyl-THF;RARECHEM AL BD 0888;(3-Oxolanyl)Methanol;Tetrahydro-3-furanmethano;TETRAHYDRO-3-FURANMETHANOL;3-FuranMethanol,tetrahydro-;Tetrahydro-3-furanylmethanol;Tetrahydrofuran-3-ylmetha...
- CBNumber
- CB8457107
- Molecular Formula
- C5H10O2
- Formula Weight
- 102.13
- MOL File
- 15833-61-1.mol
TETRAHYDRO-3-FURANMETHANOL Property
- Boiling point:
- 76-77 °C4 mm Hg(lit.)
- Density
- 1.061 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.456(lit.)
- Flash point:
- 208 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- liquid
- pka
- 14.81±0.10(Predicted)
- color
- Colourless
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 340588
- Product name
- Tetrahydro-3-furanmethanol
- Purity
- contains 250 ppm BHT as inhibitor, 99%
- Packaging
- 1g
- Price
- $47.1
- Updated
- 2023/01/07
- Product number
- 340588
- Product name
- Tetrahydro-3-furanmethanol
- Purity
- contains 250 ppm BHT as inhibitor, 99%
- Packaging
- 5g
- Price
- $194
- Updated
- 2023/01/07
- Product number
- T2800
- Product name
- (Tetrahydrofuran-3-yl)methanol
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $96
- Updated
- 2025/07/31
- Product number
- T2800
- Product name
- (Tetrahydrofuran-3-yl)methanol
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $287
- Updated
- 2025/07/31
- Product number
- 340588
- Product name
- Tetrahydro-3-furanmethanol
- Purity
- contains 250 ppm BHT as inhibitor, 99%
- Packaging
- 25g
- Price
- $281
- Updated
- 2023/01/07
TETRAHYDRO-3-FURANMETHANOL Chemical Properties,Usage,Production
Uses
3-Tetrahydrofuranmethanol is an alcoholic organic compound that can be used as a pharmaceutical intermediate.
Chemical Properties
Colorless viscous liquid
General Description
Tetrahydro-3-furanmethanol was the main product formed during hydrolysis of 1,3-dioxolane compounds.
Synthesis
6482-32-2
124391-75-9
1) To a 500 mL four-necked reaction flask was added 152 g of diethyl malonate (0.95 mol) and 27.6 g of an isopropanol solution of 20% sodium isopropoxide (sodium isopropoxide content was 20%), and the reaction temperature was maintained at 25°C to 28°C. 46.5 g of 2-bromoethanol (0.372 mol) was started to be added dropwise, and then the temperature was raised to 50°C and the reaction was kept at a constant temperature for 1.5 h. After the reaction was completed, the solvent was removed by a rotary evaporator at less than 75°C and the reaction was completed. Upon completion of the reaction, the solvent was removed by rotary evaporator at less than 75°C to give diethyl 2-hydroxyethylmalonate, a colorless oily liquid with 97% purity (GC) and 94% yield. 2) To a 500 mL four-neck reaction flask was added 66.7 g of diethyl 2-hydroxyethyl malonate (0.317 mol) and 76.1 g of 20% sodium hydroxide solution, heated to 45°C, and reacted for 2 hours. After cooling to 25°C, 20% hydrochloric acid was added to adjust the pH to 6-7, then evaporated under reduced pressure at 80°C and filtered to obtain a colorless oily liquid 2-hydroxyethylmalonic acid 47.4 g (0.305 mol), purity 95% (GC), yield 96%. 3) To an autoclave was added 47.4 g of 2-hydroxyethylmalonic acid (0.305 mol), 50 g of water and 2.3 g of Cu/SiO2 catalyst. After purging the reaction vessel with nitrogen for 3-5 times, the reaction was carried out at 240°C for 4 hours. Upon completion of the reaction, the catalyst was removed by filtration to afford 36.2 g (0.280 mol) of 2-hydroxymethyl-1,4-butanediol as a colorless or light yellow oil with 96% purity (GC) and 95% yield. 4) To a 500 mL reaction flask equipped with a reflux condenser was added 36.2 g of 2-hydroxymethyl-1,4-butanediol (0.280 mol), 150 g of toluene and 1.6 g of methanesulfonic acid. After completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 25.2 g (S)-tetrahydrofuran-3-methanol (0.192 mol) as a pale yellow oil with 95% purity (GC) and 86% yield.
References
[1] Patent: CN105254598, 2016, A. Location in patent: Paragraph 0007; 0022
[2] Patent: CN103709126, 2018, B. Location in patent: Paragraph 0029; 0035; 0036; 0044
[3] Patent: CN104193701, 2016, B. Location in patent: Paragraph 0023
TETRAHYDRO-3-FURANMETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TETRAHYDRO-3-FURANMETHANOL manufacturers
- Product
- TETRAHYDRO-3-FURANMETHANOL 15833-61-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- TETRAHYDRO-3-FURANMETHANOL 15833-61-1
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21
- Product
- Tetrahydro-3-furanylmethanol 15833-61-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10