N-ACETYLTRYPTAMINE Property

Melting point:

74.0 to 78.0 °C

Boiling point:

200°C/0.2mmHg(lit.)

Density 

1.164±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

alcohol: soluble

form 

powder

pka

16.48±0.46(Predicted)

color 

White to Light yellow to Light orange

λmax

290nm(MeOH)(lit.)

CAS DataBase Reference

1016-47-3

Safety

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2933.99.8290

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

N-ACETYLTRYPTAMINE Chemical Properties,Usage,Production

Description

The Argentinian medicinal plant Prosopsis nigra contains this alkaloid of the simple indole type which has recently been isolated and characterized. It may be a direct precursor in the biosynthesis of the {:l-carboline bases.

Description

N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; ) that binds the melatonin MT₂ receptor (K_i = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway.

Uses

N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; ) that binds the melatonin MT2 receptor (Ki = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway.

Definition

ChEBI: A tryptamine compound having an acetyl substituent attached to the side-chain amino function.

Enzyme inhibitor

This partial receptor agonist (FW = 202.26 g/mol; CAS 1016-47-3; Soluble to 100 mM in DMSO) is a melatonin (or 5-methoxy-N-acetyltryptamine) mimic and is more potent than melatonin in inhibiting dopamine release fom presynaptic melatonin receptor site of rabbit retina labeled in vitro with [3H]dopamine.

storage

Room temperature

References

Moro, Graziano, Coussio, Phytochern., 14,827 (1975)