AD80
- Product Name
- AD80
- CAS No.
- 1384071-99-1
- Chemical Name
- AD80
- Synonyms
- AD80;Reaxys ID: 27131146;Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src;1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea;1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea;Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
- CBNumber
- CB03310308
- Molecular Formula
- C22H19F4N7O
- Formula Weight
- 473.43
- MOL File
- 1384071-99-1.mol
AD80 Property
- Boiling point:
- 530.9±50.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:122.0(Max Conc. mg/mL);257.69(Max Conc. mM)
Ethanol:94.0(Max Conc. mg/mL);198.55(Max Conc. mM) - pka
- 12.47±0.70(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-6926
- Product name
- AD80
- Purity
- 99.85%
- Packaging
- 1mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-6926
- Product name
- AD80
- Purity
- 99.85%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- CS-6926
- Product name
- AD80
- Purity
- 99.85%
- Packaging
- 10mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CS-6926
- Product name
- AD80
- Purity
- 99.85%
- Packaging
- 25mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- CS-6926
- Product name
- AD80
- Purity
- 99.85%
- Packaging
- 50mg
- Price
- $1200
- Updated
- 2021/12/16
AD80 Chemical Properties,Usage,Production
Biological Activity
AD80, a multi-kinase inhibitor, is more active against human RET (c-RET), BRAF, S6K, and SRC, but less active against mTOR than AD57 or AD58. Its IC50 value for RET (c-RET) is 4 nM.
in vivo
AD80 is a potent RET inhibitor with favorable pharmacokinetic profile in clinically relevant RET fusion-driven tumor models. In patient-derived xenograft species, AD80 effectively reduced RET-rearranged tumor size.
target
| Target | Value |
| Raf (Cell-free) | |
| Src < br/> (Cell-free) | |
| S6 Kinase (Cell-free) | |
| RET V804M (Cell-free assay) | 0.4 nM |
| RET V804L (Cell-free assay) | 0.6 nM |
AD80 Preparation Products And Raw materials
Raw materials
Preparation Products
AD80 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38632
- Advantage
- 58