ChemicalBook > CAS DataBase List > 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-

Product Name
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
CAS No.
1805789-54-1
Chemical Name
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
Synonyms
CT7001 hydrochloride;CT7001 HCl;CT 7001 HCl;CT-7001 HCl;1), (3R,4R)-;ICEC0942 (CT7001);PPDA-001 HCL SALT;ICEC 0942 hydrochloride;Samuraciclib HCl (ICEC0942;Samuraciclib hydrochloride
CBNumber
CB03362079
Molecular Formula
C22H31ClN6O
Formula Weight
430.98
MOL File
1805789-54-1.mol
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3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Property

storage temp. 
Store at -20°C
solubility 
DMSO: Soluble
form 
A solid
color 
White to light yellow
InChIKey
YMNPLAHCOLEZJE-ALSDZXMDNA-N
SMILES
N(C1=CC(NC[C@H]2CCNC[C@@H]2O)=NC2=C(C(C)C)C=NN12)CC1C=CC=CC=1.Cl |&1:6,11,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C831025
Product name
CT7001Hydrochloride
Packaging
10mg
Price
$540
Updated
2021/12/16
ChemScene
Product number
CS-0039275
Product name
Samuraciclib(hydrochloride)
Purity
99.98%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0039275
Product name
Samuraciclib(hydrochloride)
Purity
99.98%
Packaging
10mg
Price
$490
Updated
2021/12/16
ChemScene
Product number
CS-0039275
Product name
Samuraciclib(hydrochloride)
Purity
99.98%
Packaging
25mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0039275
Product name
Samuraciclib(hydrochloride)
Purity
99.98%
Packaging
50mg
Price
$1600
Updated
2021/12/16
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3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Chemical Properties,Usage,Production

Uses

CT7001 Hydrochloride, is a selective CDK7 inhibitor.

in vivo

Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors[1].
? The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts[1].

Animal Model:Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells[1]
Dosage:100 mg/kg
Administration:Oral gavage; daily; for 14 days
Result:At day 14, tumor growth was inhibited by 60%.

IC 50

CDK7: 41 nM (IC50); CDK2: 578 nM (IC50); CDK1: 1.8 μM (IC50); CDK4: 49 μM (IC50); CDK5: 9.4 μM (IC50); CDK6: 34 μM (IC50); CDK9: 1.2 μM (IC50)

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Suppliers

China 56 India 1 United States 5 Global 62
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1805789-54-1, 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-Related Search:


  • 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
  • PPDA-001 HCL SALT
  • ICEC0942 (CT7001)
  • (3R,4R)-4-(((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-olhydrochloride
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  • ICEC0942;ICE C0942;ICE-C0942;CT7001;CT-7001;CT 7001
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  • Samuraciclib HCl (ICEC0942
  • CDK,Samuraciclib hydrochloride,CT 7001,ATP-competitive,Samuraciclib,inhibit,Apoptosis,deregulation,Inhibitor,CT7001,non-covalent,phosphorylates,ICEC-0942,anti-tumor,CT-7001,Asp155,cycle,CDK7,ICEC 0942,arrest,ICEC0942,PolII,Cyclin dependent kinase
  • CT 7001 HCl
  • CT7001 HCl
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  • 1805789-54-1