PQR530

Product Name: PQR530
CAS No.: 1927857-61-1
Chemical Name: PQR530
Synonyms: PQR530;CPD1536;PQR530, 10 mM in DMSO;PQR530;PQR 530;PQR-530;(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine;PQR 530,Inhibitor,PQR530,Phosphoinositide 3-kinase,PI3K,inhibit,Mammalian target of Rapamycin,mTOR;4-(difluoromethyl)-5-[4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]pyridin-2-amine;2-Pyridinamine, 4-(difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-
CBNumber: CB03362615
Molecular Formula: C18H23F2N7O2
Formula Weight: 407.42
MOL File: 1927857-61-1.mol

More

Less

PQR530 Property

Boiling point:: 660.7±65.0 °C(Predicted)
Density: 1.338±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.33 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 5.05±0.10(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 28563
Product name: PQR530
Purity: ≥98%
Packaging: 1mg
Price: $95
Updated: 2026/04/30

Cayman Chemical

Product number: 28563
Product name: PQR530
Purity: ≥98%
Packaging: 5mg
Price: $256
Updated: 2026/04/30

Cayman Chemical

Product number: 28563
Product name: PQR530
Purity: ≥98%
Packaging: 10mg
Price: $464
Updated: 2026/04/30

Cayman Chemical

Product number: 28563
Product name: PQR530
Purity: ≥98%
Packaging: 25mg
Price: $1037
Updated: 2026/04/30

ChemScene

Product number: CS-0028216
Product name: PQR530
Purity: 99.93%
Packaging: 100mg
Price: $1250
Updated: 2021/12/16

More

Less

PQR530 Chemical Properties,Usage,Production

Uses

PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar Kd toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity[1][2].

IC 50

mTOR: 0.33 nM (Kd); PI3Kα: 0.84 nM (Kd); PI3Kβ: 6.1 nM (Kd); PI3Kγ: 10 nM (Kd); PI3Kδ: 11 nM (Kd); PI3KC2β: 100 nM (Kd)

References

[1] Denise Rageot, et al. Abstract 140: Discovery and biological evaluation of PQR530, a highly potent dual pan-PI3K/mTORC1/2 inhibitor. Cancer Res 2017;77(13 Suppl).
[2] Rageot D, et al. (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. J Med Chem. 2019;62(13):6241-62 DOI:10.1021/acs.jmedchem.9b00525

PQR530 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PQR530 Suppliers

China 43 India 1 United States 2 USA 1 Global 47

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Zhengzhou Alfachem Co.,Ltd.

Tel: 0371-53778726 18003825608
Fax: 2885354392
Email: liuxiaoyan@alfachem.cn
Country: China
ProdList: 1988
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9955
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

1927857-61-1, PQR530Related Search:

PPQ-102 IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea PQR620 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

CPD1536

PQR530

4-(difluoromethyl)-5-[4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]pyridin-2-amine

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine

PQR530;PQR 530;PQR-530

2-Pyridinamine, 4-(difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-

PQR 530,Inhibitor,PQR530,Phosphoinositide 3-kinase,PI3K,inhibit,Mammalian target of Rapamycin,mTOR

PQR530, 10 mM in DMSO

1927857-61-1

C18H23F2N7O2