PQR530

Product Name: PQR530
CAS No.: 1927857-61-1
Chemical Name: PQR530
Synonyms: PQR530;CPD1536;PQR530, 10 mM in DMSO;PQR530;PQR 530;PQR-530;(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine;PQR 530,Inhibitor,PQR530,Phosphoinositide 3-kinase,PI3K,inhibit,Mammalian target of Rapamycin,mTOR;4-(difluoromethyl)-5-[4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]pyridin-2-amine;2-Pyridinamine, 4-(difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-
CBNumber: CB03362615
Molecular Formula: C18H23F2N7O2
Formula Weight: 407.42
MOL File: 1927857-61-1.mol

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PQR530 Property

Boiling point:: 660.7±65.0 °C(Predicted)
Density: 1.338±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.33 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 5.05±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028216
Product name: PQR530
Purity: 99.93%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0028216
Product name: PQR530
Purity: 99.93%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PRK0000451
Product name: (S)-4-(DIFLUOROMETHYL)-5-(4-(3-METHYLMORPHOLINO)-6-MORPHOLINO-1,3,5-TRIAZIN-2-YL)PYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $450.27
Updated: 2021/12/16

ChemScene

Product number: CS-0028216
Product name: PQR530
Purity: 99.93%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0028216
Product name: PQR530
Purity: 99.93%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

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PQR530 Chemical Properties,Usage,Production

Uses

PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar Kd toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity[1][2].

IC 50

mTOR: 0.33 nM (Kd); PI3Kα: 0.84 nM (Kd); PI3Kβ: 6.1 nM (Kd); PI3Kγ: 10 nM (Kd); PI3Kδ: 11 nM (Kd); PI3KC2β: 100 nM (Kd)

References

[1] Denise Rageot, et al. Abstract 140: Discovery and biological evaluation of PQR530, a highly potent dual pan-PI3K/mTORC1/2 inhibitor. Cancer Res 2017;77(13 Suppl).
[2] Rageot D, et al. (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. J Med Chem. 2019;62(13):6241-62 DOI:10.1021/acs.jmedchem.9b00525

PQR530 Preparation Products And Raw materials

Raw materials

Preparation Products

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PQR530 Suppliers

China 42 India 1 United States 2 USA 1 Global 46

Shanghai Boyle Chemical Co., Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Zhengzhou Alfachem Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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Shanghai Biopharmaleader Co., Ltd.

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Twochem Co.Ltd.

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Jinan Yaoyan Pharmaceutical Co., Ltd.

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1927857-61-1, PQR530Related Search:

PPQ-102 IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea PQR620 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

CPD1536

PQR530

4-(difluoromethyl)-5-[4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]pyridin-2-amine

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine

PQR530;PQR 530;PQR-530

2-Pyridinamine, 4-(difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-

PQR 530,Inhibitor,PQR530,Phosphoinositide 3-kinase,PI3K,inhibit,Mammalian target of Rapamycin,mTOR

PQR530, 10 mM in DMSO

1927857-61-1

C18H23F2N7O2