IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
- Product Name
- IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
- CAS No.
- 196868-63-0
- Chemical Name
- IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
- Synonyms
- PQ401;CS-764;PQ401, >=98%;3β-Hydroxy-8;PQ-401; PQ 401;24-lanostadiene;IGF-1R Inhibitor II;PQ401 hydrochloride;24-Lanostadien-3β-ol;IGF-1R Inhibitor II, PQ401
- CBNumber
- CB72094589
- Molecular Formula
- C18H16ClN3O2
- Formula Weight
- 341.79
- MOL File
- 196868-63-0.mol
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Property
- Density
- 1.370±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: >10mg/mL
- form
- White solid
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P0113
- Product name
- PQ401
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 407248
- Product name
- IGF-1R Inhibitor II, PQ401
- Packaging
- 10mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 20979
- Product name
- PQ401
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20979
- Product name
- PQ401
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 20979
- Product name
- PQ401
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Chemical Properties,Usage,Production
Uses
PQ 401, a novel diarylurea compound, is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) autophosphorylation. Also used as a potential testing agent in the treatment of breast and other IGF-1-sensitive cancers.
Definition
ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines.
Biological Activity
Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .
in vivo
a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1].
storage
Store at +4°C
References
[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79.
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea manufacturers
- Product
- IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea 196868-63-0
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-18