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4-AMINO-2-METHYLQUINOLINE

Product Name
4-AMINO-2-METHYLQUINOLINE
CAS No.
6628-04-2
Chemical Name
4-AMINO-2-METHYLQUINOLINE
Synonyms
4-AMINOQUINALDINE;2-METHYLQUINOLIN-4-AMINE;NSC 60281;AKOS AUF2104;4-AMinoquinald;4-Quinaldinamine;TIMTEC-BB SBB003992;5-4-Aminoquinaldine;4-Aminoquinaldine,98%;LABOTEST-BB LT02084860
CBNumber
CB6227904
Molecular Formula
C10H10N2
Formula Weight
158.2
MOL File
6628-04-2.mol
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4-AMINO-2-METHYLQUINOLINE Property

Melting point:
162-166 °C(lit.)
Boiling point:
333 °C(lit.)
Density 
1.1606 (estimate)
vapor pressure 
0.001Pa at 25℃
refractive index 
1.7080 (estimate)
Flash point:
333°C
storage temp. 
2-8°C, protect from light
solubility 
soluble in Methanol
form 
powder to crystal
pka
9.40±0.50(Predicted)
color 
White to Orange to Green
Water Solubility 
Soluble in water.
BRN 
118323
Stability:
Hygroscopic
InChIKey
COCFIBRMFPWUDW-UHFFFAOYSA-N
LogP
1.77
CAS DataBase Reference
6628-04-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
RIDADR 
3259
WGK Germany 
3
HazardClass 
8
PackingGroup 
III
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A79000
Product name
4-Aminoquinaldine
Purity
98%
Packaging
5g
Price
$82.8
Updated
2025/07/31
Sigma-Aldrich
Product number
05851
Product name
4-Aminoquinaldine
Purity
matrix substance for MALDI-MS, ≥99.0% (HPLC)
Packaging
1g
Price
$409
Updated
2022/05/15
TCI Chemical
Product number
A0415
Product name
4-Amino-2-methylquinoline
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$139
Updated
2025/07/31
TCI Chemical
Product number
A0415
Product name
4-Amino-2-methylquinoline
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$413
Updated
2025/07/31
Sigma-Aldrich
Product number
A79000
Product name
4-Aminoquinaldine
Purity
98%
Packaging
25g
Price
$339
Updated
2025/07/31
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4-AMINO-2-METHYLQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

SLIGHTLY BEIGE TO LIGHT YELLOW POWDER

Uses

4-Amino-2-methylquinoline is used as a pharmaceutical intermediate.

Flammability and Explosibility

Non flammable

Synthesis

4295-06-1

6628-04-2

General procedure for the synthesis of 4-amino-2-methylquinoline from 2-methyl-4-chloroquinoline: In an oven-dried vial (35 × 12 mm) fitted with a PTFE-sealed screw cap, a magnetic stirring bar, [(±)-BINAP]Ni[P(OPh)3]2-2PhCH3 (39 mg, 0.025 mmol, 5 mol%), (±)- BINAP (15 mg, 0.025 mmol, 5 mol%) and the corresponding aryl halide (0.50 mmol, 1.0 equiv). The vial was transferred to an argon filled glove box and NaOtBu (216 mg, 2.20 mmol, 4.40 equiv) and NH3 (0.5 M in 1,4-dioxane, 3.0 mL, 1.5 mmol, 3.0 equiv) were added sequentially. After sealing the reaction vial, it was removed from the glove box and placed in an oil bath preheated to 120°C with stirring for 18 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with ether (15 mL) and washed sequentially with 1 M NaOH (10 mL) and water (10 mL). The organic phase was dried over anhydrous sodium sulfate, concentrated and loaded onto silica gel, and purified by fast column chromatography (ethyl acetate/hexane or ethyl acetate/methanol) to afford the target product aniline analog. 4-Amino-2-methylquinoline (19 mg, 0.23 mmol, 46%) was obtained as an orange solid from 4-chloro-2-methylquinoline (100 mg, 0.500 mmol), operated according to the above general method and purified by fast column chromatography (ethyl acetate/methanol 90:10). The spectral data of the product were in agreement with literature reports [32]. Thin layer chromatography Rf = 0.23 (ethyl acetate/methanol 90:10).1H NMR (500 MHz, CDCl3) δ: 8.06 (1H, d, J = 8.4 Hz, Ar-H), 7.96 (1H, d, J = 8.4 Hz, Ar-H), 7.72 (1H, t, J = 7.7 Hz, Ar-H), 7.50 (1H, t, J = 7.7 Hz, Ar-H), 7.50 (1H, t, J = 7.7 Hz, Ar-H), 7.08 (1H, s, Ar-H), 2.66 (3H, s, CH3), 2.07 (2H, br s, NH2).13C NMR (125 MHz, CDCl3) δ: 159.6 (Ar-C), 149.2 (Ar-C), 145.8 (Ar-C), 130.1 (Ar-CH ), 129.5 (Ar-C), 125.6 (Ar-CH), 120.5 (Ar-CH), 120.1 (Ar-CH), 109.0 (Ar-CH), 25.7 (CH3).

References

[1] Chemistry - A European Journal, 2011, vol. 17, # 35, p. 9599 - 9604
[2] Angewandte Chemie - International Edition, 2015, vol. 54, # 12, p. 3773 - 3777
[3] Angew. Chem., 2015, vol. 127, # 12, p. 3844 - 3848,5
[4] Australian Journal of Chemistry, 2015, vol. 68, # 12, p. 1842 - 1853
[5] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1933, vol. 113, p. 293,298

4-AMINO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

4-CHLORO-2-METHYLQUINOLINE

Preparation Products

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4-AMINO-2-METHYLQUINOLINE Suppliers

Americas 1 China 186 Europe 1 Germany 6 India 6 Japan 2 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 8 United States 19 Global 233
Hefei NaNo Biological Technology Co., Ltd.
Tel
0551-65629887 18010855303
Fax
0551-65629887
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sales@hfnhsw.com
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China
ProdList
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Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
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China
ProdList
2297
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Zibo Junlida Chemical Co. , Ltd.
Tel
18560270963
Email
1258536883@qq.com
Country
China
ProdList
537
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58
Jiangsu Greature Bio-Medicine Co., Ltd.
Tel
0512-85557988 18662338937
Fax
0512-85557182
Email
frank.wang@greature.com.cn
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China
ProdList
147
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Energy Chemical
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021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
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China
ProdList
44894
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Cangzhou Dongen Technology Co., Ltd
Tel
18631716282
Email
1175897318@qq.com
Country
China
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Hefei Qiming Pharmaceutical Technology Co., Ltd
Tel
19810657371
Email
123642210@qq.com
Country
China
ProdList
818
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Wuhan Amixiang Chemical Co., Ltd
Tel
15871785420; 15871785420
Email
3642720642@qq.com
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China
ProdList
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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View Lastest Price from 4-AMINO-2-METHYLQUINOLINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-AMINO-2-METHYLQUINOLINE 6628-04-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-28
Hebei Zhanyao Biotechnology Co. Ltd
Product
4-AMINO-2-METHYLQUINOLINE 6628-04-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Aminoquinaldine 6628-04-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

6628-04-2, 4-AMINO-2-METHYLQUINOLINERelated Search:

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE 1,1'-(Decane-1,10-diyl)bis(4-amino-2-methylquinoline-1-ium)·2chloride quindecamine TACRINE HYDROCHLORIDE 4-AMINO-2-METHYLQUINOLINE 4-AMINO-2-METHYLQUINOLINE-6-CARBOXYLIC ACID,PURITY:95% MIN(HPLC),4-amino-2-methylquinoline-6-carboxylicacid ethyl4-amino-2-methylquinoline-6-carboxylate 6-AMINO-2-METHYLQUINOLINE,6-Amino-2-methylquinoline,97% 2-AMINO-3-METHYLQUINOLINE 5-AMINO-2-METHYLQUINOLINE 3-AMINO-2-METHYLQUINOLINE 8-AMINO-2-METHYLQUINOLINE 98+%,8-Aminoquinaldine(8-Amino-2-Methylquinoline),8-Amino-2-methylquinoline Hcl,8-AMINO-2-METHYLQUINOLINE 3-AMINO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID,3-Amino-2-methylquinoline-4-carboxylic acid, 95+% 3-AMINO-4-METHYLQUINOLINE 7-Amino-4-methylquinoline-2(1H)-one Quinaldine 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HCL HYDRATE IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

  • LABOTEST-BB LT02084860
  • AKOS AUF2104
  • 4-AMINOQUINALDINE
  • 4-AMINO-2-METHYLQUINOLINE
  • TIMTEC-BB SBB003992
  • 2-Methyl-4-quinolinamine
  • 4-Quinolinamine, 2-methyl-
  • 2-METHYLQUINOLIN-4-YLAMINE
  • 2-METHYLQUINOLIN-4-AMINE
  • Dequalinium Impurity 1（Dequalinium EP Impurity A）
  • 4-Aminoquinaldine,98%
  • 4-AMINO-2-METHYLQUINOLINE 98%
  • 2-Methyl-4-aminoquinoline
  • 4-AMinoquinald
  • 4-Quinaldinamine
  • NSC 60281
  • 4-Amino-2-methylquinoline &gt
  • 4-Amino-2-methylchinolin
  • 4-AMINO-2-METHYLQUINOLINE ISO 9001：2015 REACH
  • Dequalinium Chloride EP Impurity AQ: What is Dequalinium Chloride EP Impurity A Q: What is the CAS Number of Dequalinium Chloride EP Impurity A
  • 5-4-Aminoquinaldine
  • C10225000 4-Aminoquinaldine
  • Dequalinium Impurity 1
  • 2-Methyl-5-chloro-8-hydroxyquinoline
  • 6628-04-2
  • 6628-4-2
  • Building Blocks
  • Aminoquinolines
  • Alkylquinolines
  • Quinolines
  • Heterocyclic Building Blocks
  • Quinaldines
  • Alkylquinolines
  • Aminoquinolines
  • quinoline
  • Quinolines
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Quinaldines