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TACRINE HYDROCHLORIDE

Product Name
TACRINE HYDROCHLORIDE
CAS No.
1684-40-8
Chemical Name
TACRINE HYDROCHLORIDE
Synonyms
TACRINE;COGNEX;TACRINE HCL;hydroaminacrine;ci970;ROMOTAL;tenakrin;THA Dihydrate;Romotal Dihydrate;Tenakrin Dihydrate
CBNumber
CB5402661
Molecular Formula
C13H15ClN2
Formula Weight
234.72
MOL File
1684-40-8.mol
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TACRINE HYDROCHLORIDE Property

Melting point:
280-284 °C(lit.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in aqueous buffers
pka
pKa 9.8 (Uncertain)
form 
Crystalline solid
color 
White to light yellow
CAS DataBase Reference
1684-40-8(CAS DataBase Reference)
EPA Substance Registry System
Tacrine hydrochloride (1684-40-8)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
25-36/37/38-20/22
Safety Statements 
26-36-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
AR9532500
HazardClass 
6.1(a)
PackingGroup 
II
Toxicity
LD50 intravenous in mouse: 5600ug/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J60070
Product name
Tacrine hydrochloride
Packaging
5g
Price
$215.65
Updated
2024/03/01
Cayman Chemical
Product number
70240
Product name
Tacrine (hydrochloride)
Packaging
1000mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
70240
Product name
Tacrine (hydrochloride)
Packaging
5000mg
Price
$117
Updated
2024/03/01
Tocris
Product number
0965
Product name
Tacrine hydrochloride
Purity
≥99%(HPLC)
Packaging
100
Price
$73
Updated
2021/12/16
Usbiological
Product number
256797
Product name
Tacrine hydrochloride
Packaging
100mg
Price
$296
Updated
2021/12/16
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TACRINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Tacrine is the first therapeutic launched specifically for the treatment of Alzheimer's disease which affects four million people in the US alone. Clinically significant improvement in cognition has been demonstrated in the patients with Alzheimer's disease. Although the cause of Alzheimer's disease is not understood, degeneration of cholinergic neurons is thought to be a primary factor in the development and progression of the disease. Tacrine is a reversible acetylcholinesterase inhibitor that presumably acts centrally by elevating the acetylcholine level in the cerebral cortex and by slowing degradation of acetylcholine from intact cholinergic neurons. While tacrine improves the symptoms of Alzheimer's disease, the underlining cause of the dementing process is not altered. It has also been suggested that the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems.

Description

Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Formulations containing tacrine have been used clinically in the treatment of Alzheimer’s disease.

Chemical Properties

Pale Yellow Solid

Originator

NIH (U.S.A.)

Uses

A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi

Uses

A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.

Uses

anticholinesterase, cognitive adjuvant, K channel blocker

brand name

Cognex (Sciele).

General Description

Tacrine hydrochloride,1,2,3,4-tetrahydro-9-aminoacridine hydrochloride (THA,Cognex), is a reversible cholinesterase inhibitor that hasbeen used in the treatment of Alzheimer disease for severalyears. The drug has been used to increase the levels of AChin these patients on the basis of observations from autopsiesthat concentrations of ChAT and AChE are markedly reducedin the brain, whereas the number of muscarinic receptorsis almost normal. The use of the drug is not withoutcontroversy, as conflicting results on efficacy have been reported.The drug has been used in mild-to-moderateAlzheimer dementia.

General Description

Yellow needles (from concentrated hydrochloric acid); white powder. pH of 1.5% solution: 4.5-6. Bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

TACRINE HYDROCHLORIDE is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides . Neutralize bases in slightly exothermic reactions.

Fire Hazard

Flash point data for TACRINE HYDROCHLORIDE are not available; however, TACRINE HYDROCHLORIDE is probably combustible.

Biological Activity

Potent cholinesterase inhibitor, a cognition enhancer in vivo .

Metabolism

Tacrine is extensively metabolized by CYP450 to at least three metabolites. The major metabolite, 1-hydroxy-tacrine, is active. Its elimination half-life is between 1.5 and 4 hours, with metabolites being are excreted via the urine.

TACRINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TACRINE HYDROCHLORIDE Suppliers

Hubei zhonglong Kangsheng Fine Chemical Co., Ltd
Tel
027-027-83850178 18162590268
Fax
027-83850178
Email
1984393783@qq.com
Country
China
ProdList
3722
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
EnciPharmatech Co., Ltd
Tel
025-52714267-66 13813902930
Fax
86 025 52714266
Email
stephen_shengll@hotmail.com
Country
China
ProdList
232
Advantage
64
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
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View Lastest Price from TACRINE HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
TACRINE HYDROCHLORIDE 1684-40-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
TACRINE HYDROCHLORIDE 1684-40-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

1684-40-8, TACRINE HYDROCHLORIDERelated Search:


  • 1,2,3,4-tetrahydro-9-acridinaminmonohydrochloride
  • 1,2,3,4-tetrahydro-9-aminoacridinehydrochloride
  • 1,2,3,4-tetrahydro-9-amino-acridinmonohydrochloride
  • 9-amino-1,2,3,4-tetrahydro-acridinhydrochloride
  • tacrine monohydrochloride
  • 1,2,3,4-TETRAHYDRO-9-ACRYDINAMINEHCLMONOHYDRATE
  • 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINEHYDROCHLORIDEMONOHYDRATE
  • 1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate
  • 9-Amino-1,2,3,4-tetrahydroacridine, Hydrochloride Dihydrate
  • Hydroaminacrine Dihydrate
  • Romotal Dihydrate
  • Tacrine Hydrochloride Dihydrate
  • Tenakrin Dihydrate
  • THA Dihydrate
  • 1,2,3,4-tetrahydroacridin-9-amine monohydrochloride
  • 9-AMINO-1,2,3,4-TETRAHYDROACRIDINEHYDROC HLORIDE HY
  • 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDRO -CHLORIDE (TACRINE, TH
  • 9-Amino-1,2,3,4-tetrahydroacridine hydrate hydrochloride
  • tacrine hydrochloride, Tetrahydroaminacrine hydrate hydrochloride, THA hydrate hydrochloride
  • 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate,THA hydrochloride hydrate, Tetrahydroaminacrine hydrochloride hydrate, tacrine hydrochloride
  • Tacrine Hydrochloride (500 mg)
  • Tacrine Hydrochloride, Monohydrate, USP
  • 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE
  • ROMOTAL
  • TACRINE
  • TACRINE HCL
  • TACRINE HYDROCHLORIDE
  • ci970
  • hydroaminacrine
  • tacrinhydrochloride
  • tenakrin
  • tetrahydroaminacrin
  • COGNEX
  • 1,2,3,4-TETRAHYDRO-5-AMINOACRIDINE HYDROCHLORIDE
  • 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE, MONOHYDROCHLORIDE
  • TACRINE HYDROCHLORIDE USP/EP/BP
  • Tacrine Hydrochloride (1642700)
  • 1684-40-8
  • C13H14N2HCl
  • AMINE
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Cholinesterase, acetyl
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • COGNEX
  • Chemical Amines
  • Amines
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
  • Acetylcholine receptor