1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

Product Name: 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
CAS No.: 321-64-2
Chemical Name: 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
Synonyms: 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE;Tetrahydroaminoacridine;C01453;acrine;cs12602;CS 12602;AKOS 221-09;Tacrine 321-64-2;BUTTPARK 20\04-06;Tetrahydroaminocrin
CBNumber: CB7699634
Molecular Formula: C13H14N2
Formula Weight: 198.26
MOL File: 321-64-2.mol

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1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Property

Melting point:: 183.5℃
Boiling point:: 325.59°C (rough estimate)
Density: 0.9827 (rough estimate)
refractive index: 1.4400 (estimate)
storage temp.: 4°C, away from moisture and light
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9?+-.0.20(Predicted)
color: White to Pale Yellow
CAS DataBase Reference: 321-64-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PH011632
Product name: 1,2,3,4-tetrahydro-9-acridinamine
Purity: AldrichCPR
Packaging: 500mg
Price: $172
Updated: 2023/06/20

American Custom Chemicals Corporation

Product number: API0004308
Product name: TACRINE
Purity: 95.00%
Packaging: 0.5G
Price: $682
Updated: 2021/12/16

Acrotein

Product number: H-0509
Product name: 1,2,3,4-Tetrahydro-9-aminoacridine
Purity: 97%
Packaging: 1g
Price: $174.17
Updated: 2021/12/16

ACHEMBLOCK

Product number: P38835
Product name: 1,2,3,4-Tetrahydro-9-aminoacridine
Purity: 95%
Packaging: 1G
Price: $235
Updated: 2021/12/16

Ambeed

Product number: A295785
Product name: 1,2,3,4-Tetrahydroacridin-9-amine
Purity: 98%
Packaging: 25g
Price: $337
Updated: 2021/12/16

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1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Chemical Properties,Usage,Production

Description

In the 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In the 1960s, tacrine was used to reverse the effects of phencyclidine-like drugs. It was also marketed for many years as a respiratory stimulant. In 1993, the US Food and Drug Administration approved tacrine for the treatment of symptoms of mild to moderate Alzheimer’s disease.

Uses

The current use of tacrine is limited due to its poor oral bioavailability, the necessity for four daily doses, and serious side effects (including nausea, vomiting, dry mouth, indigestion, diarrhea, loss of appetite, urinary incontinence, collapse, convulsions, and hepatotoxicity). Currently, newer cholinesterase inhibitors (such as donepezil, rivastigmine, and galantamine) are preferred over tacrine.

Definition

ChEBI: Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+).

Synthesis Reference(s)

Tetrahedron Letters, 4, p. 1277, 1963 DOI: 10.1039/jr9630005127

Toxicity evaluation

Tacrine has numerous mechanisms of action. The putative principal mechanism of action of tacrine for Alzheimer’s disease is reversible inhibition of acetylcholinesterase (AChE), which thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase activity. In addition, tacrine blocks sodium and potassium channels. Tacrine also acts as a histamine N-methyltransferase inhibitor.
At a therapeutic dose, tacrine causes liver toxicity. Cytotoxicity studies using the human liver cell line HepG2 showed that a therapeutic blood concentration of tacrine induces reactive oxygen species production and glutathione depletion, suggesting that oxidative stress might be involved in tacrine hepatotoxicity.

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Preparation Products And Raw materials

Raw materials

Chloral hydrate 2-Aminobenzonitrile Isatin Sodium acetate trihydrate ISATIN-3-OXIME Glycine Zinc dichloride Hydroxylamine hydrochloride Cyclohexanone

Preparation Products

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1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Suppliers

Belgium 1 China 87 Europe 1 France 2 Germany 3 India 1 South Korea 1 Ukraine 1 United Kingdom 6 United States 15 Global 118

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9809
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 15881143215
Email: liangli@happysyn.com
Country: China
ProdList: 1849
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

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View Lastest Price from 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE 321-64-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: tacrine 321-64-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

321-64-2, 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINERelated Search:

9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+% 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE, MONOHYDROCHLORIDE,1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate Velnacrine N-Butyl-1,2,3,4-tetrahydro-9-acridinamine 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Acridine 9-AMINOACRIDINE 5-Chloro-1,2,3,4-tetrahydro-9-morpholinoacridine hydrochloride 9-AMINO-3,3-DIMETHYL-3,4-DIHYDRO-1(2H)-ACRIDINONE Centbucridine 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE 9-(BENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDIN-1-OL, MALEATE TA-03 9-AMINO-7-METHYL-1,2,3,4-TETRAHYDROACRIDINE 9-AMINO-6-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HCL HYDRATE Suronacrine

1,2,3,4-Tetrahydro-5-aminoacridine

1,2,3,4-tetrahydro-9-acridinamin

1,2,3,4-tetrahydro-9-amino-acridin

1,2,3,4-Tetrahydro-9-aminoacridine

5-Amino-6,7,8,9-tetrahydroacridine

Acridine, 1,2,3,4-tetrahydro-9-amino-

Acridine, 9-amino-1,2,3,4-tetrahydro-

Acridine, 9-aminotetrahydro-

CS 12602

cs12602

Tetrahydroaminacrine

Tetrahydroaminoacridine

Tetrahydroaminocrin

Tetrahydroaminocrine

BUTTPARK 20\04-06

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

9-AMINO-1,2,3,4-TETRAHYDROACRIDINE

9-AMINOTETRAHYDROACRIDINE

AKOS 221-09

TIMTEC-BB SBB003560

1,2,3,4-tetrahydroacridin-9-amine

Tacrine (base and/or unspecified salts)

1,2,3,4-Tetrahydro-acridin-9-ylamine

C01453

Tacrine 321-64-2

1,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate, 97%

9-AcridinaMine, 1,2,3,4-tetrahydro-

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE USP/EP/BP

acrine

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE，HPLC≥97%

321-64-2

C13H14N2HClH2O