1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- Product Name
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- CAS No.
- 321-64-2
- Chemical Name
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- Synonyms
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE;Tetrahydroaminoacridine;C01453;acrine;cs12602;CS 12602;AKOS 221-09;Tacrine 321-64-2;BUTTPARK 20\04-06;Tetrahydroaminocrin
- CBNumber
- CB7699634
- Molecular Formula
- C13H14N2
- Formula Weight
- 198.26
- MOL File
- 321-64-2.mol
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Property
- Melting point:
- 183.5℃
- Boiling point:
- 325.59°C (rough estimate)
- Density
- 0.9827 (rough estimate)
- refractive index
- 1.4400 (estimate)
- storage temp.
- 4°C, away from moisture and light
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9?+-.0.20(Predicted)
- color
- White to Pale Yellow
- CAS DataBase Reference
- 321-64-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PH011632
- Product name
- 1,2,3,4-tetrahydro-9-acridinamine
- Purity
- AldrichCPR
- Packaging
- 500mg
- Price
- $172
- Updated
- 2023/06/20
- Product number
- API0004308
- Product name
- TACRINE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $682
- Updated
- 2021/12/16
- Product number
- H-0509
- Product name
- 1,2,3,4-Tetrahydro-9-aminoacridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $174.17
- Updated
- 2021/12/16
- Product number
- P38835
- Product name
- 1,2,3,4-Tetrahydro-9-aminoacridine
- Purity
- 95%
- Packaging
- 1G
- Price
- $235
- Updated
- 2021/12/16
- Product number
- A295785
- Product name
- 1,2,3,4-Tetrahydroacridin-9-amine
- Purity
- 98%
- Packaging
- 25g
- Price
- $337
- Updated
- 2021/12/16
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Chemical Properties,Usage,Production
Description
In the 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In the 1960s, tacrine was used to reverse the effects of phencyclidine-like drugs. It was also marketed for many years as a respiratory stimulant. In 1993, the US Food and Drug Administration approved tacrine for the treatment of symptoms of mild to moderate Alzheimer’s disease.
Uses
The current use of tacrine is limited due to its poor oral bioavailability, the necessity for four daily doses, and serious side effects (including nausea, vomiting, dry mouth, indigestion, diarrhea, loss of appetite, urinary incontinence, collapse, convulsions, and hepatotoxicity). Currently, newer cholinesterase inhibitors (such as donepezil, rivastigmine, and galantamine) are preferred over tacrine.
Definition
ChEBI: Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+).
Synthesis Reference(s)
Tetrahedron Letters, 4, p. 1277, 1963 DOI: 10.1039/jr9630005127
Toxicity evaluation
Tacrine has numerous mechanisms of action. The putative
principal mechanism of action of tacrine for Alzheimer’s
disease is reversible inhibition of acetylcholinesterase (AChE),
which thereby slows the breakdown of the chemical messenger
acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase
activity. In addition, tacrine blocks sodium
and potassium channels. Tacrine also acts as a histamine
N-methyltransferase inhibitor.
At a therapeutic dose, tacrine causes liver toxicity. Cytotoxicity
studies using the human liver cell line HepG2 showed that
a therapeutic blood concentration of tacrine induces reactive
oxygen species production and glutathione depletion, suggesting
that oxidative stress might be involved in tacrine
hepatotoxicity.
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- jaeger@biotrend.com
- Country
- Germany
- ProdList
- 249
- Advantage
- 65
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
View Lastest Price from 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE manufacturers
- Product
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE 321-64-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- tacrine 321-64-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14