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2-Aminobenzonitrile

Product Name
2-Aminobenzonitrile
CAS No.
1885-29-6
Chemical Name
2-Aminobenzonitrile
Synonyms
ANTHRANILONITRILE;Aminobenzonitrile;2-CYANOANILINE;Benzonitrile, 2-amino-;AKOS 91125;2-CYANANILINE;O-CYANOANILINE;JACS-1885-29-6;O-aminonitrile;Anthranilonotrile
CBNumber
CB0766038
Molecular Formula
C7H6N2
Formula Weight
118.14
MOL File
1885-29-6.mol
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2-Aminobenzonitrile Property

Melting point:
45-48 °C (lit.)
Boiling point:
267-268 °C (lit.)
Density 
1.11 g/cm3 (50℃)
refractive index 
1.5500 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Crystalline Flakes
pka
0.77(at 25℃)
color 
Yellow to beige-brown
Water Solubility 
INSOLUBLE
BRN 
907187
InChIKey
HLCPWBZNUKCSBN-UHFFFAOYSA-N
LogP
0.901
CAS DataBase Reference
1885-29-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzonitrile, 2-amino-(1885-29-6)
EPA Substance Registry System
Benzonitrile, 2-amino- (1885-29-6)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
20/21/22-36/37/38-43
Safety Statements 
26-36/37-36
RIDADR 
3276
WGK Germany 
2
RTECS 
CB4575000
TSCA 
T
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269095
Toxicity
LD50 ivn-mus: 180 mg/kg CSLNX* NX#00381
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A89901
Product name
2-Aminobenzonitrile
Purity
98%
Packaging
25g
Price
$65.6
Updated
2024/03/01
Sigma-Aldrich
Product number
A89901
Product name
2-Aminobenzonitrile
Purity
98%
Packaging
100g
Price
$184
Updated
2024/03/01
TCI Chemical
Product number
A0861
Product name
2-Aminobenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
A0861
Product name
2-Aminobenzonitrile
Purity
>98.0%(GC)
Packaging
100g
Price
$70
Updated
2024/03/01
Alfa Aesar
Product number
A12286
Product name
2-Aminobenzonitrile, 98%
Packaging
50g
Price
$53.3
Updated
2024/03/01
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2-Aminobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

It is a chemically stable yellow solid that readily forms salts when it encounters acid. It can be oxidized to nitrogen oxide by oxidants but has certain toxicity. The substance is easily soluble in common organic solvents but hardly soluble in low-polarity solvents, and it is insoluble in water.

Uses

2-Aminobenzonitrile is used for induction of nitrilase activity in Arthrobacter and for radioprotective agent.

Preparation

Synthesis of 2-Aminobenzonitrile: 2-Aminobenzamide was dehydrated to 2-aminobenzonitrile without protection of the amino group in the presence of phenylphosphonyl dichloride and pyridine. The highest yield of 96% was obtained using reagent 2d, while reagents 2a-c yielded less than 60%.

The reagents used for the reaction included phosphoryl chloride (2a), phenyl phosphoryl dichloride (2b), 4-chlorophenyl phosphoryl dichloride (2c), and phenylphosphonic dichloride (2d) in pyridine.
synthesis of aminobenzonitrile by dehydration of aminobenzamide using phenylphosphonic dichloride in pyridine

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 5933, 1974 DOI: 10.1021/ja00825a039
The Journal of Organic Chemistry, 43, p. 944, 1978 DOI: 10.1021/jo00399a030
Tetrahedron Letters, 32, p. 1007, 1991 DOI: 10.1016/S0040-4039(00)74473-X
Improving a process for the preparation of 2-aminobenzonitrile by reduction of 2-nitrobenzonitrile.

Safety Profile

Poison by intravenous route. Seealso NITRILES. When heated to decomposition it emitstoxic fumes of NOx and CN- .

2-Aminobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Aminobenzonitrile Suppliers

Changzhou Gabriel Chemical Co., Ltd.
Tel
13961111278
Email
731967165@qq.com
Country
China
ProdList
14
Advantage
58
Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1218
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5902
Advantage
65
Ningbo Taikang Chemical Co., Ltd.
Tel
0574-87365517 18074210286
Fax
87367735
Email
sales@taikangchem.com
Country
China
ProdList
303
Advantage
58
Shouguang Xinghai Chemical Co. LTD
Tel
15666881566
Email
449211804@qq.com
Country
China
ProdList
42
Advantage
58
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
Tel
21-54820552
Fax
086-21-64964478
Email
188738128@qq.com
Country
China
ProdList
309
Advantage
66
SHANGHAI INSPO CHEMICAL CO.,LTD
Tel
18917565227
Email
inspo@inspochem.com
Country
China
ProdList
150
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58
HuBei ShengBaoLai Biological Technology Co., Ltd
Tel
027-59105235 13007105135
Fax
027-59105235
Email
sbl1120@163.com
Country
China
ProdList
107
Advantage
55
NINGBO JL NEW MATERIAL CO.,LTD
Tel
0574-88552218 18969899212
Email
sales@jlbio-tech.cn
Country
China
ProdList
715
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from 2-Aminobenzonitrile manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
2-Aminobenzonitrile 1885-29-6
Price
US $20.00-18.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
200tons
Release date
2023-08-29
Zhengzhou Lingzhiyue Technology Co., Ltd
Product
2-Aminobenzonitrile 1885-29-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
9999
Release date
2023-10-28
Hebei Kingfiner Technology Development Co.Ltd
Product
2-Aminobenzonitrile 1885-29-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2024-06-24

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