TACRINE HYDROCHLORIDE
- Product Name
- TACRINE HYDROCHLORIDE
- CAS No.
- 1684-40-8
- Chemical Name
- TACRINE HYDROCHLORIDE
- Synonyms
- TACRINE;COGNEX;TACRINE HCL;hydroaminacrine;ci970;ROMOTAL;tenakrin;THA Dihydrate;Romotal Dihydrate;Tenakrin Dihydrate
- CBNumber
- CB5402661
- Molecular Formula
- C13H15ClN2
- Formula Weight
- 234.72
- MOL File
- 1684-40-8.mol
TACRINE HYDROCHLORIDE Property
- Melting point:
- 280-284 °C(lit.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in aqueous buffers
- pka
- pKa 9.8 (Uncertain)
- form
- Crystalline solid
- color
- White to light yellow
- CAS DataBase Reference
- 1684-40-8(CAS DataBase Reference)
- EPA Substance Registry System
- Tacrine hydrochloride (1684-40-8)
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 25-36/37/38-20/22
- Safety Statements
- 26-36-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- AR9532500
- HazardClass
- 6.1(a)
- PackingGroup
- II
- Toxicity
- LD50 intravenous in mouse: 5600ug/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J60070
- Product name
- Tacrine hydrochloride
- Packaging
- 5g
- Price
- $215.65
- Updated
- 2024/03/01
- Product number
- 70240
- Product name
- Tacrine (hydrochloride)
- Packaging
- 1000mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 70240
- Product name
- Tacrine (hydrochloride)
- Packaging
- 5000mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 0965
- Product name
- Tacrine hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 100
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 256797
- Product name
- Tacrine hydrochloride
- Packaging
- 100mg
- Price
- $296
- Updated
- 2021/12/16
TACRINE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Tacrine is the first therapeutic launched specifically for the treatment of Alzheimer's disease which affects four million people in the US alone. Clinically significant improvement in cognition has been demonstrated in the patients with Alzheimer's disease. Although the cause of Alzheimer's disease is not understood, degeneration of cholinergic neurons is thought to be a primary factor in the development and progression of the disease. Tacrine is a reversible acetylcholinesterase inhibitor that presumably acts centrally by elevating the acetylcholine level in the cerebral cortex and by slowing degradation of acetylcholine from intact cholinergic neurons. While tacrine improves the symptoms of Alzheimer's disease, the underlining cause of the dementing process is not altered. It has also been suggested that the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems.
Description
Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Formulations containing tacrine have been used clinically in the treatment of Alzheimer’s disease.
Chemical Properties
Pale Yellow Solid
Originator
NIH (U.S.A.)
Uses
A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi
Uses
A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.
Uses
anticholinesterase, cognitive adjuvant, K channel blocker
brand name
Cognex (Sciele).
General Description
Tacrine hydrochloride,1,2,3,4-tetrahydro-9-aminoacridine hydrochloride (THA,Cognex), is a reversible cholinesterase inhibitor that hasbeen used in the treatment of Alzheimer disease for severalyears. The drug has been used to increase the levels of AChin these patients on the basis of observations from autopsiesthat concentrations of ChAT and AChE are markedly reducedin the brain, whereas the number of muscarinic receptorsis almost normal. The use of the drug is not withoutcontroversy, as conflicting results on efficacy have been reported.The drug has been used in mild-to-moderateAlzheimer dementia.
General Description
Yellow needles (from concentrated hydrochloric acid); white powder. pH of 1.5% solution: 4.5-6. Bitter taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
TACRINE HYDROCHLORIDE is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides . Neutralize bases in slightly exothermic reactions.
Fire Hazard
Flash point data for TACRINE HYDROCHLORIDE are not available; however, TACRINE HYDROCHLORIDE is probably combustible.
Biological Activity
Potent cholinesterase inhibitor, a cognition enhancer in vivo .
Metabolism
Tacrine is extensively metabolized by CYP450 to at least three metabolites. The major metabolite, 1-hydroxy-tacrine, is active. Its elimination half-life is between 1.5 and 4 hours, with metabolites being are excreted via the urine.
TACRINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TACRINE HYDROCHLORIDE manufacturers
- Product
- TACRINE HYDROCHLORIDE 1684-40-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- TACRINE HYDROCHLORIDE 1684-40-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27