ChemicalBook > CAS DataBase List > 4-AMINO-2-METHYLQUINOLINE

4-AMINO-2-METHYLQUINOLINE

Product Name: 4-AMINO-2-METHYLQUINOLINE
CAS No.: 6628-04-2
Chemical Name: 4-AMINO-2-METHYLQUINOLINE
Synonyms: 4-AMINOQUINALDINE;2-METHYLQUINOLIN-4-AMINE;NSC 60281;AKOS AUF2104;4-AMinoquinald;4-Quinaldinamine;TIMTEC-BB SBB003992;5-4-Aminoquinaldine;4-Aminoquinaldine,98%;LABOTEST-BB LT02084860
CBNumber: CB6227904
Molecular Formula: C10H10N2
Formula Weight: 158.2
MOL File: 6628-04-2.mol

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4-AMINO-2-METHYLQUINOLINE Property

Melting point:: 162-166 °C(lit.)
Boiling point:: 333 °C(lit.)
Density: 1.1606 (estimate)
vapor pressure: 0.001Pa at 25℃
refractive index: 1.7080 (estimate)
Flash point:: 333°C
storage temp.: 2-8°C, protect from light
solubility: soluble in Methanol
form: powder to crystal
pka: 9.40±0.50(Predicted)
color: White to Orange to Green
Water Solubility: Soluble in water.
BRN: 118323
Stability:: Hygroscopic
InChIKey: COCFIBRMFPWUDW-UHFFFAOYSA-N
LogP: 1.77
CAS DataBase Reference: 6628-04-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: 3259
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A79000
Product name: 4-Aminoquinaldine
Purity: 98%
Packaging: 5g
Price: $82.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 05851
Product name: 4-Aminoquinaldine
Purity: matrix substance for MALDI-MS, ≥99.0% (HPLC)
Packaging: 1g
Price: $409
Updated: 2022/05/15

TCI Chemical

Product number: A0415
Product name: 4-Amino-2-methylquinoline
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $139
Updated: 2025/07/31

TCI Chemical

Product number: A0415
Product name: 4-Amino-2-methylquinoline
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $413
Updated: 2025/07/31

Sigma-Aldrich

Product number: A79000
Product name: 4-Aminoquinaldine
Purity: 98%
Packaging: 25g
Price: $339
Updated: 2025/07/31

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4-AMINO-2-METHYLQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

SLIGHTLY BEIGE TO LIGHT YELLOW POWDER

Uses

4-Amino-2-methylquinoline is used as a pharmaceutical intermediate.

Flammability and Explosibility

Non flammable

Synthesis

4295-06-1

6628-04-2

General procedure for the synthesis of 4-amino-2-methylquinoline from 2-methyl-4-chloroquinoline: In an oven-dried vial (35 × 12 mm) fitted with a PTFE-sealed screw cap, a magnetic stirring bar, [(±)-BINAP]Ni[P(OPh)3]2-2PhCH3 (39 mg, 0.025 mmol, 5 mol%), (±)- BINAP (15 mg, 0.025 mmol, 5 mol%) and the corresponding aryl halide (0.50 mmol, 1.0 equiv). The vial was transferred to an argon filled glove box and NaOtBu (216 mg, 2.20 mmol, 4.40 equiv) and NH3 (0.5 M in 1,4-dioxane, 3.0 mL, 1.5 mmol, 3.0 equiv) were added sequentially. After sealing the reaction vial, it was removed from the glove box and placed in an oil bath preheated to 120°C with stirring for 18 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with ether (15 mL) and washed sequentially with 1 M NaOH (10 mL) and water (10 mL). The organic phase was dried over anhydrous sodium sulfate, concentrated and loaded onto silica gel, and purified by fast column chromatography (ethyl acetate/hexane or ethyl acetate/methanol) to afford the target product aniline analog. 4-Amino-2-methylquinoline (19 mg, 0.23 mmol, 46%) was obtained as an orange solid from 4-chloro-2-methylquinoline (100 mg, 0.500 mmol), operated according to the above general method and purified by fast column chromatography (ethyl acetate/methanol 90:10). The spectral data of the product were in agreement with literature reports [32]. Thin layer chromatography Rf = 0.23 (ethyl acetate/methanol 90:10).1H NMR (500 MHz, CDCl3) δ: 8.06 (1H, d, J = 8.4 Hz, Ar-H), 7.96 (1H, d, J = 8.4 Hz, Ar-H), 7.72 (1H, t, J = 7.7 Hz, Ar-H), 7.50 (1H, t, J = 7.7 Hz, Ar-H), 7.50 (1H, t, J = 7.7 Hz, Ar-H), 7.08 (1H, s, Ar-H), 2.66 (3H, s, CH3), 2.07 (2H, br s, NH2).13C NMR (125 MHz, CDCl3) δ: 159.6 (Ar-C), 149.2 (Ar-C), 145.8 (Ar-C), 130.1 (Ar-CH ), 129.5 (Ar-C), 125.6 (Ar-CH), 120.5 (Ar-CH), 120.1 (Ar-CH), 109.0 (Ar-CH), 25.7 (CH3).

References

[1] Chemistry - A European Journal, 2011, vol. 17, # 35, p. 9599 - 9604
[2] Angewandte Chemie - International Edition, 2015, vol. 54, # 12, p. 3773 - 3777
[3] Angew. Chem., 2015, vol. 127, # 12, p. 3844 - 3848,5
[4] Australian Journal of Chemistry, 2015, vol. 68, # 12, p. 1842 - 1853
[5] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1933, vol. 113, p. 293,298

4-AMINO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

4-CHLORO-2-METHYLQUINOLINE

Preparation Products

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View Lastest Price from 4-AMINO-2-METHYLQUINOLINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMINO-2-METHYLQUINOLINE 6628-04-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-28

Hebei Zhanyao Biotechnology Co. Ltd

Product: 4-AMINO-2-METHYLQUINOLINE 6628-04-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Aminoquinaldine 6628-04-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

6628-04-2, 4-AMINO-2-METHYLQUINOLINERelated Search:

LABOTEST-BB LT02084860

AKOS AUF2104

4-AMINOQUINALDINE

4-AMINO-2-METHYLQUINOLINE

TIMTEC-BB SBB003992

2-Methyl-4-quinolinamine

4-Quinolinamine, 2-methyl-

2-METHYLQUINOLIN-4-YLAMINE

2-METHYLQUINOLIN-4-AMINE

Dequalinium Impurity 1（Dequalinium EP Impurity A）

4-Aminoquinaldine,98%

4-AMINO-2-METHYLQUINOLINE 98%

2-Methyl-4-aminoquinoline

4-AMinoquinald

4-Quinaldinamine

NSC 60281

4-Amino-2-methylquinoline &gt

4-Amino-2-methylchinolin

4-AMINO-2-METHYLQUINOLINE ISO 9001：2015 REACH

Dequalinium Chloride EP Impurity AQ: What is Dequalinium Chloride EP Impurity A Q: What is the CAS Number of Dequalinium Chloride EP Impurity A

5-4-Aminoquinaldine

C10225000 4-Aminoquinaldine

Dequalinium Impurity 1

2-Methyl-5-chloro-8-hydroxyquinoline

6628-04-2

6628-4-2

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