IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

ChemicalBook > CAS DataBase List > IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

Product Name: IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
CAS No.: 196868-63-0
Chemical Name: IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
Synonyms: PQ401;CS-764;PQ401, >=98%;3β-Hydroxy-8;PQ-401; PQ 401;24-lanostadiene;IGF-1R Inhibitor II;PQ401 hydrochloride;24-Lanostadien-3β-ol;IGF-1R Inhibitor II, PQ401
CBNumber: CB72094589
Molecular Formula: C18H16ClN3O2
Formula Weight: 341.79
MOL File: 196868-63-0.mol

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IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Property

Density: 1.370±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: >10mg/mL
form: White solid
color: white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0113
Product name: PQ401
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Sigma-Aldrich

Product number: 407248
Product name: IGF-1R Inhibitor II, PQ401
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 20979
Product name: PQ401
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20979
Product name: PQ401
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 20979
Product name: PQ401
Packaging: 10mg
Price: $122
Updated: 2024/03/01

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IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Chemical Properties,Usage,Production

Uses

PQ 401, a novel diarylurea compound, is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) autophosphorylation. Also used as a potential testing agent in the treatment of breast and other IGF-1-sensitive cancers.

Definition

ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines.

Biological Activity

Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .

in vivo

a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1].

storage

Store at +4°C

References

[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79.

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea manufacturers

Career Henan Chemical Co

Product: IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea 196868-63-0
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

196868-63-0, IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)ureaRelated Search:

PQR-309(PI3K-IN-2) PP2 PPQ-102 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine PQR620 PQR530 Linsitinib BMS-754807 4-AMINO-2-METHYLQUINOLINE IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

PQ401

N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea

IGF-1R Inhibitor II

N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea

Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-

1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea PQ401

PQ 401 N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea

PQ401, >=98%

IGF-1R Inhibitor II, PQ401

PQ401 hydrochloride

PQ-401; PQ 401

CS-764

IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea

24-Lanostadien-3β-ol

24-lanostadiene

3β-Hydroxy-8

IGF-1R Inhibitor II PQ-401 PQ-01

PQ 401, Cell-permeable IGF1R inhibitor

196868-63-0

196868-30-8

Inhibitors