PPQ-102

Product Name: PPQ-102
CAS No.: 931706-15-9
Chemical Name: PPQ-102
Synonyms: PPQ-102;CS-1365;CFTR Inhibitor;PPQ 102, >=98%;PPQ-102, 10 mM in DMSO;PPQ-102, CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
CBNumber: CB82628279
Molecular Formula: C26H22N4O3
Formula Weight: 438.48
MOL File: 931706-15-9.mol

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PPQ-102 Property

Melting point:: >300℃ (ethanol )
Boiling point:: 648.7±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: -20C
solubility: DMF: 0.2 mg/ml
form: White crystalline solid
pka: 1.00±0.40(Predicted)
color: Light yellow to yellow
InChI: 1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3
InChIKey: MNOOVRNGPIWJDI-UHFFFAOYSA-N
SMILES: [n]21c(c5[n]([c]([n]([c](c5c2c6ccccc6)=O)C)=O)C)C(Nc4c1cccc4)c3[o]c(cc3)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219677
Product name: CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
Packaging: 10mg
Price: $242
Updated: 2026/03/19

Cayman Chemical

Product number: 16275
Product name: PPQ-102
Purity: ≥95%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 16275
Product name: PPQ-102
Purity: ≥95%
Packaging: 10mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 16275
Product name: PPQ-102
Purity: ≥95%
Packaging: 50mg
Price: $710
Updated: 2024/03/01

Tocris

Product number: 4303
Product name: PPQ102
Purity: ≥98%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

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PPQ-102 Chemical Properties,Usage,Production

Uses

PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].

General Description

A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.

storage

Store at -20°C

References

[1] Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. DOI:10.1021/jm9009873

PPQ-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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PPQ-102 Suppliers

China 76 India 1 United Kingdom 1 United States 16 Global 94

Shanghai Boyle Chemical Co., Ltd.

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Sigma-Aldrich

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931706-15-9, PPQ-102Related Search:

PQR-309(PI3K-IN-2) PP2 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea PQR620 PQR530

CS-1365

CFTR Inhibitor

CFTR INHIBITOR; PPQ102; PPQ 102

CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem

PPQ-102

7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE

PPQ-102, CFTR Inhibitor

6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione

7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin

6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102

PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione

PPQ 102, >=98%

Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-

7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

polycystic kidney disease,E13.5 embryonic kidneys,inhibit,Inhibitor,PPQ-102,CFTR,Cystic fibrosis transmembrane conductance regulator

PPQ-102, 10 mM in DMSO

931706-15-9

Inhibitors