PPQ-102
- Product Name
- PPQ-102
- CAS No.
- 931706-15-9
- Chemical Name
- PPQ-102
- Synonyms
- PPQ-102;CS-1365;CFTR Inhibitor;PPQ 102, >=98%;PPQ-102, CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
- CBNumber
- CB82628279
- Molecular Formula
- C26H22N4O3
- Formula Weight
- 438.48
- MOL File
- 931706-15-9.mol
PPQ-102 Property
- Melting point:
- >300℃ (ethanol )
- Boiling point:
- 648.7±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- -20C
- solubility
- DMF: 0.2 mg/ml
- form
- White crystalline solid
- pka
- 1.00±0.40(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 219677
- Product name
- CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
- Packaging
- 10mg
- Price
- $259
- Updated
- 2024/03/01
- Product number
- 16275
- Product name
- PPQ-102
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 16275
- Product name
- PPQ-102
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 16275
- Product name
- PPQ-102
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $710
- Updated
- 2024/03/01
- Product number
- 4303
- Product name
- PPQ102
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $730
- Updated
- 2021/12/16
PPQ-102 Chemical Properties,Usage,Production
General Description
A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
storage
Store at -20°C
PPQ-102 Preparation Products And Raw materials
Raw materials
Preparation Products
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