PPQ-102

Product Name: PPQ-102
CAS No.: 931706-15-9
Chemical Name: PPQ-102
Synonyms: PPQ-102;CS-1365;CFTR Inhibitor;PPQ 102, >=98%;PPQ-102, CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
CBNumber: CB82628279
Molecular Formula: C26H22N4O3
Formula Weight: 438.48
MOL File: 931706-15-9.mol

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PPQ-102 Property

Melting point:: >300℃ (ethanol )
Boiling point:: 648.7±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: -20C
solubility: DMF: 0.2 mg/ml
form: White crystalline solid
pka: 1.00±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219677
Product name: CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
Packaging: 10mg
Price: $259
Updated: 2024/03/01

Cayman Chemical

Product number: 16275
Product name: PPQ-102
Purity: ≥95%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 16275
Product name: PPQ-102
Purity: ≥95%
Packaging: 10mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 16275
Product name: PPQ-102
Purity: ≥95%
Packaging: 50mg
Price: $710
Updated: 2024/03/01

Tocris

Product number: 4303
Product name: PPQ102
Purity: ≥98%(HPLC)
Packaging: 50
Price: $730
Updated: 2021/12/16

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PPQ-102 Chemical Properties,Usage,Production

General Description

A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.

storage

Store at -20°C

PPQ-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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PPQ-102 Suppliers

China 59 India 1 United Kingdom 1 United States 16 Global 77

Shanghai Boyle Chemical Co., Ltd.

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Email: sales@boylechem.com
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Email: info@chemexpress.com
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MedChemexpress LLC

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AdooQ Bioscience CHINA

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Email: info@adooq.cn
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Shanghai JiYi Biotechnology Co. Ltd.

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Sigma-Aldrich

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Shanghai Lollane Biological Technology Co.,Ltd.

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SPIRO PHARMA

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ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
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Email: siyansales@126.com
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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931706-15-9, PPQ-102Related Search:

PQR-309(PI3K-IN-2) PP2 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea PQR620 PQR530

CS-1365

CFTR Inhibitor

CFTR INHIBITOR; PPQ102; PPQ 102

CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem

PPQ-102

7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE

PPQ-102, CFTR Inhibitor

6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione

7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin

6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102

PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione

PPQ 102, >=98%

Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-

7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

polycystic kidney disease,E13.5 embryonic kidneys,inhibit,Inhibitor,PPQ-102,CFTR,Cystic fibrosis transmembrane conductance regulator

7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

931706-15-9

Inhibitors