Acid-PEG6-SS-PEG6-Acid

Product Name: Acid-PEG6-SS-PEG6-Acid
CAS No.: 2055014-97-4
Chemical Name: Acid-PEG6-SS-PEG6-Acid
Synonyms: Bis-(PEG6-acid)-SS;Acid-PEG6-SS-PEG6-Acid;4,7,10,13,16,19,26,29,32,35,38,41-Dodecaoxa-22,23-dithiatetratetracontanedioic acid
CBNumber: CB03363834
Molecular Formula: C30H58O16S2
Formula Weight: 738.9
MOL File: 2055014-97-4.mol

More

Less

Acid-PEG6-SS-PEG6-Acid Property

Boiling point:: 782.6±60.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
pka: 3.97±0.10(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

BroadPharm

Product number: BP-22791
Product name: Acid-PEG6-SS-PEG6-acid
Purity: 98%
Packaging: 500mg
Price: $850
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1007
Product name: Acid-PEG6-SS-PEG6-Acid
Packaging: 250mg
Price: $1026
Updated: 2021/12/16

More

Less

Acid-PEG6-SS-PEG6-Acid Chemical Properties,Usage,Production

Description

Acid-PEG6-SS-PEG6-acid is a homobifunctional cleavable linker. The terminal carboxylic acids can react with primary amines in the presences of activators such as EDC and HATU to form stable amide bonds. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. PEG6 spacer increase the compound;s solubility.

Uses

Bis-(PEG6-acid)-SS is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Acid-PEG6-SS-PEG6-Acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Acid-PEG6-SS-PEG6-Acid Suppliers

China 11 United Kingdom 1 United States 4 Global 16

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 13892832556
Email: 2440688701@qq.com
Country: China
ProdList: 1994
Advantage: 58

Zhengzhou Akem Chemical Co., Ltd

Tel: 13303867194
Email: 3001317055@qq.com
Country: China
ProdList: 9681
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 5061
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 32050
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Taizhou Chuanxu Pharmaceutical Technology Co., Ltd.

Tel: 13000000000
Email: 974144639@qq.com
Country: China
ProdList: 9979
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 176345344 7 17634854698
Email: 1959525201@qq.com
Country: China
ProdList: 10000
Advantage: 58

2055014-97-4, Acid-PEG6-SS-PEG6-AcidRelated Search:

Acid-PEG2-SS-PEG2-Acid Acid-PEG4-S-S-PEG4-Acid Acid-PEG3-SS-PEG3-Acid Acid-PEG3-PFP ester

Acid-PEG6-SS-PEG6-Acid

Bis-(PEG6-acid)-SS

4,7,10,13,16,19,26,29,32,35,38,41-Dodecaoxa-22,23-dithiatetratetracontanedioic acid

2055014-97-4

C30H58O16S2