Acid-PEG3-SS-PEG3-Acid

Product Name: Acid-PEG3-SS-PEG3-Acid
CAS No.: 2055014-98-5
Chemical Name: Acid-PEG3-SS-PEG3-Acid
Synonyms: Acid-PEG3-SS-PEG3-Acid;3-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethyldisulfanyl]ethoxy]ethoxy]ethoxy]propanoic acid
CBNumber: CB43363832
Molecular Formula: C18H34O10S2
Formula Weight: 474.59
MOL File: 2055014-98-5.mol

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Acid-PEG3-SS-PEG3-Acid Property

Boiling point:: 631.7±55.0 °C(Predicted)
Density: 1.245±0.06 g/cm3(Predicted)
pka: 3.97±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific

Product number: BIPG1005
Product name: Acid-PEG3-SS-PEG3-Acid
Packaging: 250mg
Price: $1026
Updated: 2021/12/16

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Acid-PEG3-SS-PEG3-Acid Chemical Properties,Usage,Production

Description

Acid-PEG3-SS-PEG3-acid is a is a homobifunctional, cleavable PEG linker. Carboxylic acids can react with primary amines in the presences of activators such as EDC and HATU. The disulfide bonds can be cleaved by Dithiothreitol (DTT) reagent. PEG spacer increase the compound's solubility.

Uses

Acid-PEG3-SS-PEG3-acid is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Acid-PEG3-SS-PEG3-Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Acid-PEG3-SS-PEG3-Acid Suppliers

China 14 United Kingdom 1 United States 3 Global 18

Bide Pharmatech Ltd.

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Jilin Chinese Academy of Sciences-yanshen Technology

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2055014-98-5, Acid-PEG3-SS-PEG3-AcidRelated Search:

Acid-PEG2-SS-PEG2-Acid Acid-PEG4-S-S-PEG4-Acid Acid-PEG6-SS-PEG6-Acid Acid-PEG3-PFP ester

Acid-PEG3-SS-PEG3-Acid

3-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethyldisulfanyl]ethoxy]ethoxy]ethoxy]propanoic acid

2055014-98-5

C18H34O10S2