Azido-PEG3-Val-Cit-PAB-OH

Product Name: Azido-PEG3-Val-Cit-PAB-OH
CAS No.: 2055024-65-0
Chemical Name: Azido-PEG3-Val-Cit-PAB-OH
Synonyms: N3-PEG3-Val-Cit-PAB;Azido-PEG3-Val-Cit-PAB-OH
CBNumber: CB03373569
Molecular Formula: C27H44N8O8
Formula Weight: 608.7
MOL File: 2055024-65-0.mol

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Azido-PEG3-Val-Cit-PAB-OH Property

solubility: Soluble in Water, DMSO, DMF

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23206
Product name: Azido-PEG3-Val-Cit-PAB-OH
Purity: 96%
Packaging: 500mg
Price: $850
Updated: 2021/12/16

BroadPharm

Product number: BP-23206
Product name: Azido-PEG3-Val-Cit-PAB-OH
Purity: 96%
Packaging: 1g
Price: $1390
Updated: 2021/12/16

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Azido-PEG3-Val-Cit-PAB-OH Chemical Properties,Usage,Production

Description

Azido-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.

Uses

Azido-PEG3-Val-Cit-PAB-OH is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Azido-PEG3-Val-Cit-PAB-OH Preparation Products And Raw materials

Raw materials

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Azido-PEG3-Val-Cit-PAB-OH Suppliers

China 18 United States 4 Global 22

Alfa Chemistry

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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Aladdin Scientific

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MedChemExpress

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View Lastest Price from Azido-PEG3-Val-Cit-PAB-OH manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Azido-PEG3-Val-Cit-PAB-OH 2055024-65-0
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-03-29

2055024-65-0, Azido-PEG3-Val-Cit-PAB-OHRelated Search:

Azido-PEG3-Val-Cit-PAB-PNP Azido-PEG3-S-PEG4-t-butyl ester Azido-PEG3-S-PEG4-propargyl Azdo-PEG3-S-PEG3-Azide Azido-PEG4-NHBoc

Azido-PEG3-Val-Cit-PAB-OH

N3-PEG3-Val-Cit-PAB

2055024-65-0

ADC LINKER