Azido-PEG4-Val-Cit-PAB-OH
- Product Name
- Azido-PEG4-Val-Cit-PAB-OH
- CAS No.
- 2055024-64-9
- Chemical Name
- Azido-PEG4-Val-Cit-PAB-OH
- Synonyms
- N3-PEG4-Val-Cit-PAB;Azido-PEG4-Val-Cit-PAB-OH;1-azido-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12-tetraoxapentadecan-15-amide
- CBNumber
- CB03373574
- Molecular Formula
- C29H48N8O9
- Formula Weight
- 652.75
- MOL File
- 2055024-64-9.mol
Azido-PEG4-Val-Cit-PAB-OH Property
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- ADC1160
- Product name
- Azido-PEG(4)-Val-Cit-PAB
- Packaging
- 100mg
- Price
- $607.5
- Updated
- 2021/12/16
- Product number
- BP-23207
- Product name
- Azido-PEG4-Val-Cit-PAB-OH
- Purity
- 96%
- Packaging
- 500mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- ADC1160
- Product name
- Azido-PEG(4)-Val-Cit-PAB
- Packaging
- 250mg
- Price
- $1215
- Updated
- 2021/12/16
Azido-PEG4-Val-Cit-PAB-OH Chemical Properties,Usage,Production
Description
Azido-PEG4-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group enable click chemistry with DBCO, BCN or other Alkyne group. PEG spacer increases aqueous solubility.
Uses
Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Protease Cleavable Linker; PEGs; Cleavable Linker
References
[1] Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. DOI:10.3390/ph11020032
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG4-Val-Cit-PAB-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG4-Val-Cit-PAB-OH manufacturers
- Product
- Azido-PEG4-Val-Cit-PAB-OH 2055024-64-9
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >95.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-29