FEXOFENADINE HYDROCHLORIDE

Product Name: FEXOFENADINE HYDROCHLORIDE
CAS No.: 138452-21-8
Chemical Name: FEXOFENADINE HYDROCHLORIDE
Synonyms: Fexofendine Hcl;FEXOFENADINE HCL;Fexofenadine Hydrochloride (200 mg);terfenidine carboxylate hydrochloride;CARBOXYTERFENADINE,TERFENADINECARBOXYLATE;Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai);2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid;2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;(+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE;ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE
CBNumber: CB0340913
Molecular Formula: C32H40ClNO4
Formula Weight: 538.12
MOL File: 138452-21-8.mol

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FEXOFENADINE HYDROCHLORIDE Property

storage temp.: −20°C
solubility: DMSO: 32 mg/mL, soluble
form: solid
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Medical Isotopes, Inc.

Product number: 10243
Product name: Fexofenadine HCl
Packaging: 100mg
Price: $850
Updated: 2021/12/16

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FEXOFENADINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

The metabolite of seldane (terfenadine), fexofenadine, was launched in the USA. A histamine H₁ receptor antagonist, fexofenadine is more effect than its parent compound without the associated side-effects.

Originator

Sepracor (USA)

Uses

Fexofenadine HCl (Allegra) is a selective, specific H1 antagonist that is structurally related to the butyrophenone tranquilizer haloperidol. It is the active carboxylic acid metabolite of terfenadine (no longer commercially available in the United States). It binds mainly to the peripheral H1 receptors, with minimal crossing of the blood–brain barrier and hence minimal sedative effects. Fexofenadine lacks the cardiotoxic effects of its parent drug, terfenadine. However, it has been associated with increased QT interval, syncope, and ventricular arrhythmia in at least one susceptible patient with preexisting cardiovascular risk. To date, no significant interactions have been demonstrated with fexofenadine when administered concomitantly with azole antifungals or macrolide antibiotics. Indicated for seasonal allergic rhinitis and chronic idiopathic urticaria.

Uses

Anti-histamine

Definition

ChEBI: Fexofenadine hydrochloride is a diarylmethane.

brand name

Allegra

Dosage forms

60 mg PO b.i.d.

FEXOFENADINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FEXOFENADINE HYDROCHLORIDE Suppliers

Canada 2 China 35 Europe 1 France 1 Germany 2 India 3 South Korea 1 United Kingdom 8 United States 13 Global 66

TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Aakash Chemicals and Dye-Stuffs, Inc.

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138452-21-8, FEXOFENADINE HYDROCHLORIDERelated Search:

FEXOFENADINE HYDROCHLORIDE Terfenadine alpha,alpha-Diphenyl-4-piperidinomethanol Diphenylpiperidin-4-ylmethanol hydrochloride Fexofenadine hydrochloride Acetic acid Fexofenadine 2-Phenylisobutyric acid THIOGLYCOLIC ACID N-BUTYL ESTER 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE (2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID Benzeneacetic acid, 4-butyl--alpha--methyl-, (-alpha-S)- (9CI) 4-N-BUTYLPHENETHYL ALCOHOL 4-(TERT-BUTYL)-ALPHA-METHYLBENZYL ALCOHOL (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID 4-(diphenylmethyl)piperidine 2-(4-PIPERIDYL)-2-PROPANOL PHENYL-PIPERIDIN-4-YL-METHANOL

terfenidine carboxylate hydrochloride

ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE

2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride

FEXOFENADINE HCL

CARBOXYTERFENADINE,TERFENADINECARBOXYLATE

Fexofendine Hcl

2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid

(+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE

Fexofenadine Hydrochloride (200 mg)

Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai)

Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-α,α-diMethyl-, hydrochloride (1:1)

138452-21-8

C32H39NO4.HCl