ChemicalBook > CAS DataBase List > 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE

Product Name
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
CAS No.
39974-94-2
Chemical Name
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
Synonyms
5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE;AKOS JY2082772;3-Formyl-5-methoxy-1-methylindole;3-Formyl-5-methoxy-1-methyl-1H-indole;5-methoxy-1-methylindole-3-carbaldehyde;5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE;5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYD;5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 5-methoxy-1-methyl-
CBNumber
CB0343873
Molecular Formula
C11H11NO2
Formula Weight
189.21
MOL File
39974-94-2.mol
More
Less

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Property

Melting point:
133-136°C
Boiling point:
357.9±22.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
Brown
Water Solubility 
It is insoluble in water.
Sensitive 
Air Sensitive
BRN 
1528827
CAS DataBase Reference
39974-94-2
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
HazardClass 
IRRITANT
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M223883
Product name
5-Methoxy-1-methyl-1H-indole-3-carbaldehyde
Packaging
100mg
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-41
Product name
5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
Packaging
1g
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
038104
Product name
5-Methoxy-1-methyl-1H-indole-3-carbaldehyde
Packaging
500mg
Price
$126
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-41
Product name
5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
Packaging
5G
Price
$340
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0027238
Product name
5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
Purity
95.00%
Packaging
500MG
Price
$683.53
Updated
2021/12/16
More
Less

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Uses

5-Methoxy-1-methylindole-3-carboxaldehyde is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

10601-19-1

74-88-4

39974-94-2

1. 5-methoxyindole-3-carboxaldehyde (300 mg, 1.71 mmol) was added to a stirring solution of sodium hydride suspension (82 mg, 2.05 mmol, 60% dispersed in mineral oil) in DMF (8 mL) in batches under argon protection, a process which needed to be completed within 5 minutes. 2. The reaction mixture was continued to be stirred for 30 minutes, followed by the addition of iodomethane (0.13 mL, 2.05 mmol) and continued stirring for 1 hour. 3. Upon completion of the reaction, 10% sodium bicarbonate solution (40 mL) was added and the mixture was extracted with ethyl acetate (4×). 4. The organic layers were combined, washed sequentially with 10% sodium bicarbonate solution (2×) and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated. 5. The crude product was purified by column chromatography (eluent: 50:50 ethyl acetate/hexane) to afford 5-methoxy-1-methylindole-3-carbaldehyde (320 mg, 99%) as a light yellow solid. Rf = 0.35 (50:50 ethyl acetate/hexane); melting point = 130-132°C (literature value: 132-133°C). 1H NMR (CDCl3): δ 9.95 (s, 1H), 7.79 (d, 1H, J = 2.4 Hz), 7.62 (s, 1H), 7.25 (d, 1H, J = 8.8 Hz), 6.96 (dd, 1H, J = 2.4 and 8.9 Hz), 3.90 (s, 3H), 3.85 (s, 3H).

References

[1] Tetrahedron, 2005, vol. 61, # 7, p. 1793 - 1801
[2] Organic Letters, 2013, vol. 15, # 11, p. 2636 - 2639
[3] Patent: US2003/8850, 2003, A1
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6261 - 6276
[5] Chemical Biology and Drug Design, 2015, vol. 86, # 4, p. 731 - 745

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Suppliers

China 54 Germany 3 India 2 Russia 1 United Kingdom 2 United States 8 Global 70
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
More
Less

View Lastest Price from 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers

Career Henan Chemical Co
Product
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 39974-94-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100JKG
Release date
2020-01-14

39974-94-2, 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDERelated Search:

Ethyl 5-acetyloxy-1,2-dimethylindole-3-carboxylate 1-Methylindole 1-Methylindole-3-carboxaldehyde 5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBALDEHYDE 2-CHLORO-1-(5-METHOXY-1,2-DIMETHYL-1H-INDOL-3-YL)-ETHANONE 5-ETHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID 5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID 5-Methoxy-4-methylindole-3-carboxaldehyde 6-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 1H-Indole-3-carboxylic acid, 6-bromo-1-(2-hydroxy-3-(4-morpholinyl)pro pyl)-5-methoxy-2-methyl-, ethyl ester, monohydrochloride 5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID ETHYL ESTER 1-BENZYL-5-METHOXY-2-METHYL-1H-INDOLE-3-CARBOXYLIC ACID 6-BROMO-5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID 1-BENZYL-5-METHOXY-2-METHYL-1H-INDOLE-3-CARBALDEHYDE AKOS BC-1855 5-(BENZYLOXY)-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-INDOLE-3-CARBALDEHYDE 3-ACETYL-1-(4-METHOXYPHENYL)-2-METHYL-1H-INDOL-5-YL 2-FUROATE AKOS BBS-00002569

  • 3-Formyl-5-methoxy-1-methylindole
  • 5-methoxy-1-methylindole-3-carbaldehyde
  • 3-Formyl-5-methoxy-1-methyl-1H-indole
  • 5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
  • 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYD
  • 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
  • 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
  • AKOS JY2082772
  • 1H-Indole-3-carboxaldehyde, 5-methoxy-1-methyl-
  • 39974-94-2