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TMS

Product Name
TMS
CAS No.
24144-92-1
Chemical Name
TMS
Synonyms
CS-961;SMB 00388;TMS, >=98%;TMS, 10 mM in DMSO;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;2,4,3',5'-Tetramethoxystilbene;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS (2,4,3',5'-tetramethoxystilbene)
CBNumber
CB0347220
Molecular Formula
C18H20O4
Formula Weight
300.35
MOL File
24144-92-1.mol
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TMS Property

Melting point:
78-79 °C
Boiling point:
459.9±40.0 °C(Predicted)
Density 
1.117±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00388
Product name
2,4,3′,5′-tetramethoxystilbene
Purity
≥98% (HPLC)
Packaging
10 mg
Price
$162
Updated
2025/07/31
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
1mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
50mg
Price
$469
Updated
2024/03/01
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TMS Chemical Properties,Usage,Production

Uses

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.

Uses

2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Uses

2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Definition

ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .

in vivo

To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) [1].

IC 50

CYP1B1: 6 nM (IC50); CYP1B1: 3 nM (Ki); CYP1A1: 300 nM (IC50); CYP1A2: 3.1 μM (IC50)

TMS Preparation Products And Raw materials

Raw materials

Preparation Products

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TMS Suppliers

Canada 1 China 79 Europe 1 Germany 2 India 2 Japan 1 United Kingdom 1 United States 17 Global 104
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Jinan Mingya Medical Technology Co., Ltd.
Tel
0531-85828981
Fax
+86-531-85806006
Email
864598798@qq.com
Country
China
ProdList
588
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
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View Lastest Price from TMS manufacturers

Career Henan Chemical Co
Product
2,4,3',5'-tetramethoxystilbene 24144-92-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

24144-92-1, TMSRelated Search:

4-NITROSTYRENE 1-TMS-1H-BENZOTRIAZOLE POLY(DIMETHYLSILOXANE-CO-METHYLHYDRO-SIL OXANE), TMS TERM, VISC CA. 260 CST Acetonitrile-d3 Benzene-D6 Tetrakis(trimethylsilyl)silane ((TMS)4Si ) Pyridine-d5, contains 1 v/v% TMS, 99 atom % D, for NMR,Pyridine-d5, with 0.03% TMS, 100.0 atom% D, for NMR Chloroform-d ACETONE-D6 TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY] N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS) Methanol-d4 TOLUENE-D8, 99 ATOM % D (CONTAINS 1% V/V TMS) N-METHYL-N-TRIMETHYLSILYLHEPTAFLUOROBUTYRAMIDE (TMS REAGENT FOR GC USING FID) 95+% DIMETHYL SULFOXIDE-D6 1-TMS-1H-BENZOTRIAZOLE 1-(TMS)ETHYNYLCYCLOHEXENE Cytochrome P450 1B1 Inhibitor, TMS

  • (E)-2,3',4,5'-TETRAMETHOXYSTILBENE
  • 2,3',4,5'-TETRAMETHOXYSTILBENE
  • 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE
  • 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
  • 3,5,2’,4’-Tetramethoxystilbene
  • TMS - Trans-2,3',4,5'-tetramethoxystilbene
  • CS-961
  • Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-
  • (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
  • TMS, >=98%
  • 5'-tetramethoxystilbene
  • SMB 00388
  • 2,4,3',5'-Tetramethoxystilbene
  • (E)-2,3'',4,5''-Tetramethoxystilbene, CYP1B1 inhibitor
  • TMS, 10 mM in DMSO
  • (E)-2,3',4,5'-Tetramethoxystilbene, CYP1B1 inhibitor
  • (E)-2,3',4,5'-Tetramethoxystilbene, CYP1B1 inhibitor
  • TMS (2,4,3',5'-tetramethoxystilbene)
  • 24144-92-1
  • Antitumour