TMS

Product Name: TMS
CAS No.: 24144-92-1
Chemical Name: TMS
Synonyms: CS-961;SMB 00388;TMS, >=98%;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;2,4,3',5'-Tetramethoxystilbene;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS - Trans-2,3',4,5'-tetramethoxystilbene;(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
CBNumber: CB0347220
Molecular Formula: C18H20O4
Formula Weight: 300.35
MOL File: 24144-92-1.mol

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TMS Property

Melting point:: 78-79 °C
Boiling point:: 459.9±40.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10038
Product name: TMS
Purity: ≥98%
Packaging: 1mg
Price: $16
Updated: 2024/03/01

Cayman Chemical

Product number: 10038
Product name: TMS
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 10038
Product name: TMS
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 10038
Product name: TMS
Purity: ≥98%
Packaging: 50mg
Price: $469
Updated: 2024/03/01

TRC

Product number: T298900
Product name: 2,4,3'',5''-Tetramethoxystilbene
Packaging: 1g
Price: $1695
Updated: 2021/12/16

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TMS Chemical Properties,Usage,Production

Uses

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.

Uses

2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Uses

2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Definition

ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .

TMS Preparation Products And Raw materials

Raw materials

Preparation Products

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TMS Suppliers

Canada 1 China 61 Europe 1 Germany 2 India 2 Japan 1 United Kingdom 1 United States 17 Global 86

MedChemexpress LLC

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Musechem

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Cckinase, Inc.

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Aladdin Scientific

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Cayman Chemical Company

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MedChemExpress

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ChemPacific Corporation

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EMD Biosciences, Inc.

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View Lastest Price from TMS manufacturers

Career Henan Chemical Co

Product: 2,4,3',5'-tetramethoxystilbene 24144-92-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

24144-92-1, TMSRelated Search:

4-NITROSTYRENE TOLUENE-D8, 99 ATOM % D (CONTAINS 1% V/V TMS) N-METHYL-N-TRIMETHYLSILYLHEPTAFLUOROBUTYRAMIDE (TMS REAGENT FOR GC USING FID) 95+% Methanol-d4 DIMETHYL SULFOXIDE-D6 1-TMS-1H-BENZOTRIAZOLE POLY(DIMETHYLSILOXANE-CO-METHYLHYDRO-SIL OXANE), TMS TERM, VISC CA. 260 CST Acetonitrile-d3 Benzene-D6 Tetrakis(trimethylsilyl)silane ((TMS)4Si ) Pyridine-d5, contains 1 v/v% TMS, 99 atom % D, for NMR,Pyridine-d5, with 0.03% TMS, 100.0 atom% D, for NMR Chloroform-d ACETONE-D6 TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY] N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS) 1-(TMS)ETHYNYLCYCLOHEXENE 1-TMS-1H-BENZOTRIAZOLE Cytochrome P450 1B1 Inhibitor, TMS

(E)-2,3',4,5'-TETRAMETHOXYSTILBENE

2,3',4,5'-TETRAMETHOXYSTILBENE

1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE

1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE

3,5,2’,4’-Tetramethoxystilbene

TMS - Trans-2,3',4,5'-tetramethoxystilbene

CS-961

Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-

(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene

TMS, >=98%

5'-tetramethoxystilbene

SMB 00388

2,4,3',5'-Tetramethoxystilbene

(E)-2,3'',4,5''-Tetramethoxystilbene, CYP1B1 inhibitor

24144-92-1

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