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2-CYANO-N-METHYL-ACETAMIDE

Product Name
2-CYANO-N-METHYL-ACETAMIDE
CAS No.
6330-25-2
Chemical Name
2-CYANO-N-METHYL-ACETAMIDE
Synonyms
Entacapone Impurity 27;Entacapone Impurity 61;Methyl 2-Cyano Acetamide;N-Methyl-2-cyanoacetamide;2-Cyan-N-methyl-acetamide;N1-METHYL-2-CYANOACETAMIDE;N-(Cyanoacetyl)methylamine;2-CYANO-N-METHYL-ACETAMIDE;Acetamide, 2-cyano-N-methyl-;4-bromo-N-propan-2-yl-1-pentanamine
CBNumber
CB0348520
Molecular Formula
C4H6N2O
Formula Weight
98.1
MOL File
6330-25-2.mol
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2-CYANO-N-METHYL-ACETAMIDE Property

Melting point:
82 °C
Boiling point:
335.3±25.0 °C(Predicted)
Density 
1.044±0.06 g/cm3(Predicted)
vapor pressure 
0.009Pa at 25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
form 
Solid
pka
5.44±0.10(Predicted)
color 
Pale Yellow
LogP
-1.96--0.445 at 25℃
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38-22
Safety Statements 
22-26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3781
Product name
2-Cyano-N-methylacetamide
Purity
min. 98.0 %
Packaging
5G
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
M3781
Product name
2-Cyano-N-methylacetamide
Purity
min. 98.0 %
Packaging
25G
Price
$225
Updated
2025/07/31
TRC
Product number
C981860
Product name
2-Cyano-N-methylacetamide
Packaging
1g
Price
$110
Updated
2021/12/16
TRC
Product number
C981860
Product name
2-Cyano-N-methylacetamide
Packaging
5g
Price
$180
Updated
2021/12/16
TRC
Product number
C981860
Product name
2-Cyano-N-methylacetamide
Packaging
25g
Price
$425
Updated
2021/12/16
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2-CYANO-N-METHYL-ACETAMIDE Chemical Properties,Usage,Production

Uses

2-Cyano-N-methylacetamide is used in the synthesis of pyridone compounds and benzimidazoles, for various pharmaceutical application.

Synthesis

105-56-6

74-89-5

6330-25-2

1. General procedure for the synthesis of 2-cyano-N-methylacetamide: 20 g (176.8 mmol) of ethyl cyanoacetate was added slowly and dropwise at 0 °C to a tetrahydrofuran (THF) solution of 10.9 g (353.6 mmol) of methylamine, which had been cooled to 0 °C. The reaction was completed with stirring. After the dropwise addition was completed, the reaction mixture was kept at 0 °C with continued stirring. Subsequently, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by recrystallization with toluene to give 16.8 g of beige solid product in 96% yield with a melting point of 99 °C.

References

[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 14
[2] Patent: US2011/124643, 2011, A1. Location in patent: Page/Page column 14
[3] Patent: US2013/178472, 2013, A1. Location in patent: Paragraph 0228
[4] Marine Drugs, 2012, vol. 10, # 6, p. 1412 - 1421
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 12, p. 5350 - 5366

2-CYANO-N-METHYL-ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CYANO-N-METHYL-ACETAMIDE Suppliers

Canada 1 China 88 Germany 2 India 3 Ukraine 2 United Kingdom 2 United States 16 Global 114
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
Enamine
Tel
--
Fax
--
Email
enamine@enamine.net
Country
Ukraine
ProdList
6216
Advantage
67
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View Lastest Price from 2-CYANO-N-METHYL-ACETAMIDE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
2-CYANO-N-METHYL-ACETAMIDE 6330-25-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-04-27
Career Henan Chemical Co
Product
2-Cyano-N-methylacetamide 6330-25-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

6330-25-2, 2-CYANO-N-METHYL-ACETAMIDERelated Search:

Cyanoacetylurea N-CYANOACETYLPYRROLIDINE N-CYANOACETYLMORPHOLINE 1-CYANOACETYLPIPERIDINE 3-Cyano-6-methyl-2(1H)-pyridinone 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one N-CYANOACETYLURETHANE 4'-CHLORO-2-CYANOACETANILIDE 2-HYDROXY-4-METHOXYMETHYL-6-METHYLNICOTINONITRILE 3-Cyano-4,6-dimethyl-2-hydroxypyridine N,N-Dimethylcyanoacetamide Acetamiprid Acetamiprid 2-Cyanoacetamide 2-CYANOACETANILIDE 2,4-DICYANO-3-ETHYL-3-METHYLGLUTARIMIDE 2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile 2-CYANO-N-(3,4-DICHLOROPHENYL)ACETAMIDE

  • N1-METHYL-2-CYANOACETAMIDE
  • 2-Cyan-N-methyl-acetamide
  • 3-Oxo-3-(methylamino)propanenitrile
  • N-Methyl-2-cyanoacetamide
  • 2-CYANO-N-METHYL-ACETAMIDE
  • N-(Cyanoacetyl)methylamine
  • Acetamide, 2-cyano-N-methyl-
  • 4-bromo-N-propan-2-yl-1-pentanamine
  • Entacapone Impurity 61
  • Entacapone Impurity 27
  • Methyl 2-Cyano Acetamide
  • 6330-25-2