ChemicalBook > CAS DataBase List > 3-(4-METHOXYPHENOXY)PROPANOIC ACID

3-(4-METHOXYPHENOXY)PROPANOIC ACID

Product Name: 3-(4-METHOXYPHENOXY)PROPANOIC ACID
CAS No.: 20811-60-3
Chemical Name: 3-(4-METHOXYPHENOXY)PROPANOIC ACID
Synonyms: AKOS BC-0464;BUTTPARK 80\07-08;IFLAB-BB F1575-0111;3-(4-METHOXYPHENOXY)PROPANOIC ACID;3-(p-Methoxyphenoxy)propionic acid;3-(p-Methoxyphenoxy)propanoic acid;Propanoic acid,3-(4-Methoxyphenoxy)-;3-(4-METHOXY-PHENOXY)-PROPIONIC ACID
CBNumber: CB0350567
Molecular Formula: C10H12O4
Formula Weight: 196.2
MOL File: 20811-60-3.mol

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3-(4-METHOXYPHENOXY)PROPANOIC ACID Property

Melting point:: 110.5 °C
Boiling point:: 321.7±17.0 °C(Predicted)
Density: 1.188±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.14±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H12O4/c1-13-8-2-4-9(5-3-8)14-7-6-10(11)12/h2-5H,6-7H2,1H3,(H,11,12)
InChIKey: SGTCAUQLJIKBMM-UHFFFAOYSA-N
SMILES: C(O)(=O)CCOC1=CC=C(OC)C=C1

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Safety

HazardClass: IRRITANT
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S542938
Product name: 3-(4-METHOXYPHENOXY)PROPIONIC ACID
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: S542938
Product name: 3-(4-METHOXYPHENOXY)PROPIONIC ACID
Purity: Aldrich
Packaging: 50mg
Price: $29.8
Updated: 2024/03/01

TRC

Product number: M219203
Product name: 3-(4-Methoxyphenoxy)propanoicAcid
Packaging: 500mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 0648AB
Product name: 3-(4-Methoxyphenoxy)propanoicacid
Packaging: 1g
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 053735
Product name: 3-(4-Methoxyphenoxy)propanoic acid
Packaging: 500mg
Price: $237
Updated: 2021/12/16

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3-(4-METHOXYPHENOXY)PROPANOIC ACID Chemical Properties,Usage,Production

Synthesis

63815-39-4

20811-60-3

General procedure for the synthesis of 3-(4-methoxyphenoxy)propionic acid from 3-(4-methoxyphenoxy)propanenitrile: 945 g (5.34 mol, 1 equiv.) of a sample of 3-(4-methoxyphenoxy)propanenitrile was loaded into a 22 L round-bottomed flask fitted with an overhead stirrer, and 4 L of concentrated hydrochloric acid was added to the stirred solid under nitrogen protection. 2 L of water was added slowly and the reaction mixture was heated to 100 °C and kept for 3.5 h, at which point the completion of the reaction was confirmed by high performance liquid chromatography (HPLC) analysis. The reaction was cooled to 10 °C by adding ice to the reaction mixture. After drying, 920 g of crude 3-(4-methoxyphenoxy)propionic acid was obtained. The crude product was dissolved in 5 L of 6 wt% sodium carbonate aqueous solution (pH=9), 2 L of dichloromethane (DCM) was added to the reaction vessel, and after thorough stirring, the organic layer was separated and discarded with a dispensing funnel. The aqueous layer was refilled into a 22 L flask and the pH of the aqueous layer was carefully adjusted to 4.0 by slowly adding 6 M hydrochloric acid.The precipitated solid was filtered and dried in a vacuum oven to give 900 g of 3-(4-methoxyphenoxy)propionic acid as a white solid (yield: 86.04%).1H NMR (450 MHz, CDCl3): δ=2.78 (t, 2H; CH2COOH); 3.70 (s, 3H; OCH3); 4.18 (t, 2H; OCH2); 6.78 (m, 4H; Ar-H).13C NMR (112.5 MHz, CDCl3): δ=34.703 (CH2COOH); 55.925 (OCH3); 64.088 (OCH2); 114.855 (CH3OCCH); 115.984 (CH2OCCH); 152.723 (CH3OC); 154.302 (CH2OC); 177.386 (COOH).

References

[1] Patent: WO2010/39256, 2010, A1. Location in patent: Page/Page column 91
[2] Patent: JP2016/41761, 2016, A. Location in patent: Paragraph 0182; 0183
[3] Patent: US9481671, 2016, B2. Location in patent: Page/Page column 68-69
[4] Patent: WO2008/150486, 2008, A2. Location in patent: Page/Page column 91
[5] ChemMedChem, 2015, vol. 10, # 12, p. 2042 - 2062

3-(4-METHOXYPHENOXY)PROPANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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20811-60-3, 3-(4-METHOXYPHENOXY)PROPANOIC ACIDRelated Search:

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BUTTPARK 80\07-08

IFLAB-BB F1575-0111

AKOS BC-0464

3-(4-METHOXYPHENOXY)PROPANOIC ACID

3-(4-METHOXY-PHENOXY)-PROPIONIC ACID

3-(p-Methoxyphenoxy)propanoic acid

3-(p-Methoxyphenoxy)propionic acid

Propanoic acid,3-(4-Methoxyphenoxy)-

20811-60-3

CARBOXYLIC ACID