2,1,3-Benzothiadiazol-5-ylmethanol
- Product Name
- 2,1,3-Benzothiadiazol-5-ylmethanol
- CAS No.
- 89795-51-7
- Chemical Name
- 2,1,3-Benzothiadiazol-5-ylmethanol
- Synonyms
- RARECHEM AL BD 1094;2,1,3-Benzothiadiazole-5-methanol;1,2,3-BENZOTHIADIAZOL-5-YLMETHANOL;2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL;benzo[c][1,2,5]thiadiazol-5-ylMethanol
- CBNumber
- CB0353063
- Molecular Formula
- C7H6N2OS
- Formula Weight
- 166.2
- MOL File
- 89795-51-7.mol
2,1,3-Benzothiadiazol-5-ylmethanol Property
- Melting point:
- 61-63
- Boiling point:
- 313.5±17.0 °C(Predicted)
- Density
- 1.466±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.59±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 89795-51-7
Safety
- Safety Statements
- 24/25
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B198208
- Product name
- Benzo[c][1,2,5]thiadiazol-5-ylmethanol
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B198208
- Product name
- Benzo[c][1,2,5]thiadiazol-5-ylmethanol
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- Y4601
- Product name
- 2,1,3-Benzothiadiazol-5-ylmethanol
- Packaging
- 1g
- Price
- $331
- Updated
- 2021/12/16
- Product number
- CHM0019138
- Product name
- 2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $684.69
- Updated
- 2021/12/16
- Product number
- CHM0019138
- Product name
- 2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1109.86
- Updated
- 2021/12/16
2,1,3-Benzothiadiazol-5-ylmethanol Chemical Properties,Usage,Production
Synthesis
16405-98-4
89795-51-7
General procedure for the synthesis of 2,1,3-benzothiadiazole-5-methanol from 2,1,3-benzothiadiazole-5-carboxylic acid: 2,1,3-benzothiadiazole-5-carboxylic acid (2.00 g, 11.11 mmol) was dissolved in tetrahydrofuran (50 mL) and the solution was cooled to 0 °C. Subsequently, triethylamine (1.80 mL, 12.87 mmol) was slowly added dropwise followed by isobutyl chloroformate (1.62 mL, 12.40 mmol). The reaction mixture was continued to be stirred at 0 °C for 30 min and then filtered into a pre-cooled mixture of sodium borohydride (0.83 g, 21.84 mmol) and ice water (20 mL). The reaction system was kept at 0 °C and stirring was continued for 30 min. Subsequently, the reaction solution was concentrated to one-fourth of the original volume and extracted with dichloromethane (3 x 50 mL). The organic phases were combined and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to afford the target product 2,1,3-benzothiadiazole-5-methanol as a white solid in 81% yield (1.50 g), which could be used for subsequent experiments without further purification.
References
[1] Patent: WO2003/87098, 2003, A1. Location in patent: Page/Page column 39
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 21, p. 3378 - 3390
2,1,3-Benzothiadiazol-5-ylmethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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