2,1,3-Benzothiadiazol-5-ylmethanol

Product Name: 2,1,3-Benzothiadiazol-5-ylmethanol
CAS No.: 89795-51-7
Chemical Name: 2,1,3-Benzothiadiazol-5-ylmethanol
Synonyms: RARECHEM AL BD 1094;2,1,3-Benzothiadiazole-5-methanol;1,2,3-BENZOTHIADIAZOL-5-YLMETHANOL;2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL;benzo[c][1,2,5]thiadiazol-5-ylMethanol
CBNumber: CB0353063
Molecular Formula: C7H6N2OS
Formula Weight: 166.2
MOL File: 89795-51-7.mol

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2,1,3-Benzothiadiazol-5-ylmethanol Property

Melting point:: 61-63
Boiling point:: 313.5±17.0 °C(Predicted)
Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.59±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 89795-51-7

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Safety

Safety Statements: 24/25

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B198208
Product name: Benzo[c][1,2,5]thiadiazol-5-ylmethanol
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B198208
Product name: Benzo[c][1,2,5]thiadiazol-5-ylmethanol
Packaging: 500mg
Price: $330
Updated: 2021/12/16

AK Scientific

Product number: Y4601
Product name: 2,1,3-Benzothiadiazol-5-ylmethanol
Packaging: 1g
Price: $331
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0019138
Product name: 2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL
Purity: 95.00%
Packaging: 1G
Price: $684.69
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0019138
Product name: 2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL
Purity: 95.00%
Packaging: 5G
Price: $1109.86
Updated: 2021/12/16

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2,1,3-Benzothiadiazol-5-ylmethanol Chemical Properties,Usage,Production

Synthesis

16405-98-4

89795-51-7

General procedure for the synthesis of 2,1,3-benzothiadiazole-5-methanol from 2,1,3-benzothiadiazole-5-carboxylic acid: 2,1,3-benzothiadiazole-5-carboxylic acid (2.00 g, 11.11 mmol) was dissolved in tetrahydrofuran (50 mL) and the solution was cooled to 0 °C. Subsequently, triethylamine (1.80 mL, 12.87 mmol) was slowly added dropwise followed by isobutyl chloroformate (1.62 mL, 12.40 mmol). The reaction mixture was continued to be stirred at 0 °C for 30 min and then filtered into a pre-cooled mixture of sodium borohydride (0.83 g, 21.84 mmol) and ice water (20 mL). The reaction system was kept at 0 °C and stirring was continued for 30 min. Subsequently, the reaction solution was concentrated to one-fourth of the original volume and extracted with dichloromethane (3 x 50 mL). The organic phases were combined and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to afford the target product 2,1,3-benzothiadiazole-5-methanol as a white solid in 81% yield (1.50 g), which could be used for subsequent experiments without further purification.

References

[1] Patent: WO2003/87098, 2003, A1. Location in patent: Page/Page column 39
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 21, p. 3378 - 3390

2,1,3-Benzothiadiazol-5-ylmethanol Preparation Products And Raw materials

Raw materials

Calcium carbonate N-Bromosuccinimide Ethanol 2,2'-Azobis(2-methylpropionitrile) Acetone Toluene Chloroform 1,4-Dioxane Aniline Ethyl acetate Hydrochloric acid Dichloromethane 3,4-Diaminotoluene Magnesium sulfate Thionyl chloride PETROLEUM ETHER

Preparation Products

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89795-51-7, 2,1,3-Benzothiadiazol-5-ylmethanolRelated Search:

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1,2,3-BENZOTHIADIAZOL-5-YLMETHANOL

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benzo[c][1,2,5]thiadiazol-5-ylMethanol

89795-51-7