ChemicalBook > CAS DataBase List > Tetramethylguanidine

Tetramethylguanidine

Product Name
Tetramethylguanidine
CAS No.
80-70-6
Chemical Name
Tetramethylguanidine
Synonyms
TMG;1,1,3,3-TETRAMETHYLGUANIDINE;TETRAMETHYL GUANIDINE;N,N,N',N'-TETRAMETHYLGUANIDINE;1,1,3,3-Tetramethyl Guanidine (TMG);N,N’-Tetramethylguanidine;N,N-1,1,3,3-TETRAMETHYLGUANIDINE;Guanidine, N,N,N',N'-tetramethyl-;uanidine;TMG)1,1,3,3-TetraMeth
CBNumber
CB0355799
Molecular Formula
C5H13N3
Formula Weight
115.18
MOL File
80-70-6.mol
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Tetramethylguanidine Property

Melting point:
-30 °C
Boiling point:
162-163 °C (lit.)
Density 
0.916 g/mL at 20 °C (lit.)
vapor pressure 
0.2 mm Hg ( 20 °C)
refractive index 
n20/D 1.469
Flash point:
140 °F
storage temp. 
Store below +30°C.
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
15.20±0.70(Predicted)
form 
Liquid
color 
APHA: ≤150
PH
12.7 (10g/l, H2O, 25℃)
Relative polarity
5.5
Odor
mild ammoniacal odor
explosive limit
1.0-7.5%(V)
Water Solubility 
miscible
Sensitive 
Air Sensitive
BRN 
969608
Dielectric constant
23.100000000000001
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive.
InChIKey
KYVBNYUBXIEUFW-UHFFFAOYSA-N
LogP
-0.49 at 20℃
CAS DataBase Reference
80-70-6(CAS DataBase Reference)
NIST Chemistry Reference
N,N,N',N'-Tetramethylguanidine(80-70-6)
EPA Substance Registry System
Guanidine, N,N,N',N'-tetramethyl- (80-70-6)
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Safety

Hazard Codes 
C
Risk Statements 
22-34-20/22-10
Safety Statements 
26-27-36/37/39-45-16
RIDADR 
UN 2920 8/PG 2
WGK Germany 
1
F 
9-23
Autoignition Temperature
222 °C
Hazard Note 
Harmful/Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29252000
Toxicity
LD50 orally in Rabbit: 835 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.21897
Product name
N,N,N′,N′-Tetramethylguanidine
Purity
for synthesis
Packaging
100mL
Price
$84.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21897
Product name
N,N,N′,N′-Tetramethylguanidine
Purity
for synthesis
Packaging
250ML
Price
$185
Updated
2024/03/01
Sigma-Aldrich
Product number
241768
Product name
1,1,3,3-Tetramethylguanidine
Purity
99%
Packaging
5ml
Price
$51.2
Updated
2024/03/01
Sigma-Aldrich
Product number
241768
Product name
1,1,3,3-Tetramethylguanidine
Purity
99%
Packaging
100ml
Price
$78.8
Updated
2024/03/01
TCI Chemical
Product number
T0148
Product name
1,1,3,3-Tetramethylguanidine
Purity
>99.0%(GC)(T)
Packaging
25mL
Price
$19
Updated
2024/03/01
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Tetramethylguanidine Chemical Properties,Usage,Production

Chemical Properties

N,N,N',N' -Tetramethylguanidine (TMG) [80-70-6], C5H13N3, Mr 115.18, is a stable, unusually strong base, pKa 13.6 (25 ℃), with a free imino group. It is a colorless to light-yellow liquid, miscible with water and common organic solvents: 0.92 g/cm3 (25 ℃), bp 160 ℃, vapor pressure 0.03 kPa (25℃).

Uses

Tetramethylguanidine (TMG) is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries. Product Data Sheet

Uses

Base employed in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.

Uses

1,1,3,3-Tetaramethylguanidine is used as a strong, non-nucleophilic base for alkylations in organic synthesis. 1,1,3,3-Tetramethylguanidine is an efficient and selective catalyst for the benzoylation of alcohols.

Flammability and Explosibility

Flammable

Synthesis

Prepared from cyanogen chloride and dimethylamine in a 1 : 2 molar ratio, TMG is used as a polyurethane foam catalyst, in the preparation of pigments for color photography, and in steroid synthesis. 

Purification Methods

Reflux it over granulated BaO, then fractionally distil it. Protect it from CO2. [Beilstein 4 IV 227.]

Tetramethylguanidine Preparation Products And Raw materials

Raw materials

Preparation Products

4-CYANOSTYRENE 4-NITROSTYRENE
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Tetramethylguanidine Suppliers

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View Lastest Price from Tetramethylguanidine manufacturers

Jinan Finer Chemical Co., Ltd
Product
Tetramethylguanidine 80-70-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
2000mt/year
Release date
2021-08-31
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Tetramethylguanidine 80-70-6
Price
US $999.00-666.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Tetramethylguanidine 80-70-6
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-31

80-70-6, TetramethylguanidineRelated Search:

Tetramethylpyrazine 6-Methyl-1,3,5-triazine-2,4-diamine Tetramethylbenzidine Tetramethylene sulfoxide Hexazinone N,N,N',N'-TETRAMETHYLGUANIDINIUM AZIDE (3-ETHYL-2-IMINO-2,3-DIHYDRO-BENZOIMIDAZOL-1-YL)-ACETIC ACID HEXAMETHYLGUANIDINIUM CHLORIDE 2-(3-ethyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)ethanol CHEMBRDG-BB 5522694 AZOLITMIN 1,3,4,6,7,8-HEXAHYDRO-1-METHYL-2H-PYRIMIDOL[1,2-A]PYRIMIDINE Tetramethylguanidine Fenprinast Clazolimine CHEMBRDG-BB 5532820 AKOS 89906 CHEMBRDG-BB 5545601

  • N,N’-Tetramethylguanidine
  • 1,1,3,3-Tetramethyl Guanidine (TMG)
  • 1,1,3,3-Tetramethylgyanidine, 97+%
  • 1,1,3,3-Tetramethylguanidine,99%
  • N,N,N,N-Tetramethy1 Guanidine
  • 1,1,3,3-Tetramethylguanidin
  • TMG
  • 1,1,3 tetramethyl guanidine
  • 1,1,3,3-Tertamethylguanidine=TMG
  • 1,1,3,3-Tetramethylguayyniaine
  • Guanidine, 1,1,3,3-tetramethyl-
  • Guanidine, N,N,N',N'-tetramethyl-
  • n,n,n’,n’-tetramethyl-guanidin
  • uanidine
  • N1,N1,N3,N3-Tetramethylguanidine
  • N,N,N',N'-Tetramethyl-α-iminomethanediamine
  • α,α-Bis(dimethylamino)methanimine
  • 1,1,3,3-TetraMethylguanidine, 99% 100GR
  • 1,1,3,3-TetraMethylguanidine, 99% 5GR
  • TetraMethylguanidine(TMG)
  • TetraMethylguanidine,1,1,3,3-TetraMethylguanidine
  • TMG)1,1,3,3-TetraMeth
  • TMG N,N,N',N'-Tetramethylguanidine
  • N,N-1,1,3,3-TETRAMETHYLGUANIDINE
  • N,N,N',N'-TETRAMETHYLGUANIDINE
  • TETRAMETHYL GUANIDINE
  • 1,1,3,3-TETRAMETHYLGUANIDINE
  • 1,1,3,3-Tetramethylguanidine &gt
  • N,N,N',N'-TETRAMETHYLGUANIDINE FOR SYNTH
  • TMG 1,1,3,3-Tetramethyl Guanidine
  • 1,1,3,3-Tetramethylguanidine extrapure AR, 99%
  • N,N,N',N'-tetramethylguanidine
  • 80-70-6
  • CH32NCNHNCH32
  • Organic Building Blocks
  • Nitrogen Compounds
  • Guanidines
  • Building Blocks
  • Various hydrocyanic acid derivatives
  • Glycosylating Reagents
  • Bioactive Small Molecules
  • Building Blocks
  • Carbohydrate Chemistry
  • Cell Biology
  • Chemical Biology
  • Chemical Synthesis
  • Guanidines
  • Nitrogen Compounds
  • Organic Building Blocks
  • T
  • Hydrocyanic acid derivatives
  • Antidote / Antibiotic / Antimicrobial
  • 80-70-6