4-Benzyloxyphenylhydrazine
- Product Name
- 4-Benzyloxyphenylhydrazine
- CAS No.
- 51145-58-5
- Chemical Name
- 4-Benzyloxyphenylhydrazine
- Synonyms
- VITAS-BB TBB000092;4-BENZYLOXYPHENYLHYDRAZINE;(4-Phenylmethoxyphenyl)hydrazine;Hydrazine, [4-(phenylmethoxy)phenyl]-
- CBNumber
- CB0356721
- Molecular Formula
- C13H14N2O
- Formula Weight
- 214.26
- MOL File
- 51145-58-5.mol
N-Bromosuccinimide Price
- Product number
- B400213
- Product name
- (4-Phenylmethoxyphenyl)hydrazine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 266424
- Product name
- 4-Benzyloxyphenylhydrazine
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- FB55433
- Product name
- 4-Benzyloxyphenylhydrazine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB55433
- Product name
- 4-Benzyloxyphenylhydrazine
- Packaging
- 1g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- 5574AH
- Product name
- 4-Benzyloxyphenylhydrazine
- Packaging
- 1g
- Price
- $171
- Updated
- 2021/12/16
4-Benzyloxyphenylhydrazine Chemical Properties,Usage,Production
Uses
(4-Phenylmethoxyphenyl)hydrazine is used as a reactant in the preparation of indolyl thiazole derivatives as xanthine oxidase inhibitors and antiinflammatory drugs.
Manufacturing Process
Preparation of 4-benzyloxyphenylhydrazine: 200 grams 4-benzyloxyaniline hydrochloride was suspended in a mixture of 264 ml concentrated hydrochloric acid, 528 ml water and 732 grams crushed ice. A solution of 62.4 grams sodium nitrite in 136 ml water was added below the surface of the stirred suspension at -10-(+/-)2°C during 10 minutes. After stirring for 1 hour at 0°C, the suspension was treated with acid-washed charcoal and filtered.
The filtrate was cooled and maintained at -8°C while a solution of 500 grams of stannous chloride in 760 ml concentrated hydrochloric acid was added with stirring. The mixture was stirred for 2 hours at -8°C and the 4- benzyloxyphenylhydrazine hydrochloride which separated was filtered off and washed with water. The product was crystallized by adding 800 ml hot water to a 3 liter solution in ethanol and had a MP of 185° to 189°C (yield 168.5 grams, 79%).